Site Selective Boron Directed Ortho Benzylation of N-Aryl Amides: Access to Structurally Diversified Dibenzoazepines
Artikel i vetenskaplig tidskrift, 2025
We present a highly selective protocol for the ortho benzylation of N-aryl amides. This method offers mild conditions, excellent site specificity, and scalability, enabling the synthesis of diarylmethane amides and dibenzoazepines. The protocol allows for one-pot diagonal dibenzylation of dianilides, creating valuable precursors for pharmaceutically active compounds and addressing limitations in current direct C-H activation methodologies.
Författare
Ganesh H. Shinde
Göteborgs universitet
Hugo Castlind
Göteborgs universitet
Ganesh S. Ghotekar
Göteborgs universitet
Francoise Mystere Amombo Noa
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Lars Öhrström
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Henrik Sundén
Göteborgs universitet
Organic Letters
1523-7060 (ISSN) 1523-7052 (eISSN)
Vol. 27 1 207-211Ämneskategorier (SSIF 2011)
Läkemedelskemi
Organisk kemi
Infrastruktur
Chalmers materialanalyslaboratorium
DOI
10.1021/acs.orglett.4c04196
Relaterade dataset
URI: http://www.ccdc.cam.ac.uk/data_request/cif