Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
Artikel i vetenskaplig tidskrift, 2025

Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardiometabolic biomarkers, subclinical CVD markers, and incident CVD. Methods: Associations between self-reported meat intake and 1272 plasma metabolites were investigated in the SCAPIS cohort (n = 8,819; ages 50–64). Meat-associated metabolites were further examined for relation with subclinical CVD markers in the POEM cohort (n = 502; age 50) and incident CVD in the EpiHealth cohort (n = 2,278; ages 45–75; 107 incident cases over 9.6 years follow-up). Meat intake was categorized into white, unprocessed red, and processed red meat. Linear regression analyzed associations between meat intake, metabolites and cardiometabolic biomarkers, and subclinical CVD markers, while Cox models evaluated association between meat-associated metabolites and incident CVD. Results: After correction for multiple testing, 458, 368, and 403 metabolites were associated with white, unprocessed red, and processed red meat, respectively. Processed red meat-associated metabolites were associated with higher levels of fasting insulin, hemoglobin A1c, and lipoprotein(a), and were inversely associated with maximal oxygen consumption. Two metabolites, 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) (hazard ratios (HR: 1.32; 95 % CI: 1.08, 1.62)) and glutamine degradant (HR: 1.35; 95 % CI: 1.07, 1.72), that were inversely associated with intake of all meat types, were also associated with a higher risk of incident CVD. Conclusions: This study provides comprehensive analysis of self-reported meat intake and plasma metabolites. The findings may enhance our understanding of the relationship between meat intake and CVD, and provide insights into underlying mechanisms.

Cardiovascular Disease

Meat intake

Population-based epidemiological study

Plasma metabolomics

Författare

Getachew Arage

Uppsala universitet

Koen F. Dekkers

Uppsala universitet

Luka Marko Rašo

Uppsala universitet

Ulf Hammar

Uppsala universitet

Ulrika Ericson

Lunds universitet

Susanna C. Larsson

Uppsala universitet

Karolinska Institutet

Hanna Engel

Uppsala universitet

Gabriel Baldanzi

Uppsala universitet

Kamalita Pertiwi

Uppsala universitet

Sergi Sayols-Baixeras

Uppsala universitet

CIBER - Centro de Investigación Biomédica en Red

Rikard Landberg

Chalmers, Life sciences, Livsmedelsvetenskap

J. Sundstrom

Uppsala universitet

University of New South Wales (UNSW)

J. Gustav Smith

Wallenberg Center for Molecular Medicine

Wallenberg Lab.

Lunds universitet

Gunnar Engström

Lunds universitet

Johan Ärnlöv

Uppsala universitet

Karolinska Institutet

Högskolan i Dalarna

M. Orho-Melander

Lunds universitet

L. Lind

Uppsala universitet

Tove Fall

Uppsala universitet

Shafqat Ahmad

Södertörns högskola

Uppsala universitet

Brigham and Women's Hospital

Metabolism: Clinical and Experimental

0026-0495 (ISSN) 15328600 (eISSN)

Vol. 168 156188

Ämneskategorier (SSIF 2025)

Folkhälsovetenskap, global hälsa och socialmedicin

Kardiologi och kardiovaskulära sjukdomar

Näringslära och dietkunskap

DOI

10.1016/j.metabol.2025.156188

PubMed

40081615

Mer information

Senast uppdaterat

2025-05-08