Nanostructured model biomaterial surfaces prepared by colloidal lithography

Artikel i vetenskaplig tidskrift, 1999

Adsorption of 110 nm negatively charged polystyrene particles on positively charged titanium surfaces was studied for the purpose of making surfaces with controlled nanotopography. Surfaces with 9-26% saturation coverages of evenly spaced particles were produced by varying the salt concentration in the particle solution (0.01-1 mM NaCl). This is a quick and relatively simple method to make uniform nanostructures over large surface areas (approx. cm2). The produced surfaces are used for in vitro cell studies of how sub-micrometre topography influences cell adhesion and function.