Estrogen receptor specificity for the effects of estrogen in ovariectomized mice.
Artikel i vetenskaplig tidskrift, 2002

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated.

Mice

genetics

Bone Density

Thymus Gland

Receptors

alpha-Macroglobulins

Complement C3

Estrogen Receptor beta

Collagen Type VIII

Uterus

Mice

genetics

genetics

Sialoglycoproteins

Interleukin-3

analysis

drug effects

Organ Size

Matrix Metalloproteinase 9

drug effects

metabolism

genetics

Estrogen Receptor alpha

RNA

Female

Liver

genetics

cytology

genetics

Messenger

Bone and Bones

Knockout

Ovariectomy

Animals

pharmacology

drug effects

genetics

cytology

drug effects

physiology

Estrogen

Estrogens

Författare

Marie K Lindberg

Göteborgs universitet

Z Weihua

Niklas Andersson

Göteborgs universitet

Sofia Movérare-Skrtic

Göteborgs universitet

Hui-Ling Gao

O Vidal

M C Erlandsson

Sara H Windahl

Göteborgs universitet

G Andersson

D B Lubahn

Catharina Lindholm

Göteborgs universitet

Karin Dahlman-Wright

J-A Gustafsson

Claes Ohlsson

Göteborgs universitet

Journal of Endocrinology

0022-0795 (ISSN)

Vol. 174 2 167-78

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

PubMed

12176656

Mer information

Skapat

2017-10-10