Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening
Artikel i vetenskaplig tidskrift, 2011

Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)2NO3], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)2]NO3 . H2O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)o. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0o. Compound I was characterized by 1H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml-1, respectively). Three different hydrogels containing I or Ag2SO4 were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself.


bonding complexes



deoxyribonucleic acid




antimicrobial activity

ag(i) complexes


Al-Shimaà A A Massoud

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Y. M. Gohar

Alexandria University

Vratislav Langer

Chalmers, Kemi- och bioteknik, Oorganisk miljökemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Frida Svensson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

J. Janis

Itä-Suomen Yliopisto

Sofie Gårdebjer

Farmaceutisk teknologi

Mölnlycke healthcare

M. Haukka

Itä-Suomen Yliopisto

Fabian Jonsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Emma Aneheim

Chalmers, Kemi- och bioteknik, Kärnkemi

Peter Löwenhielm

Mölnlycke healthcare

Morsy A. M. Abu-Youssef

Alexandria University

Lars Öhrström

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

New Journal of Chemistry

1144-0546 (ISSN) 1369-9261 (eISSN)

Vol. 35 3 640-648


Livsvetenskaper och teknik (2010-2018)





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