Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
Artikel i vetenskaplig tidskrift, 2021
COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.
proteomics
metabolomics
combined metabolic activators
omics data
COVID-19
Författare
Ozlem Altay
University of Health Sciences
Kungliga Tekniska Högskolan (KTH)
Muhammad Arif
Kungliga Tekniska Högskolan (KTH)
Xiangyu Li
Kungliga Tekniska Högskolan (KTH)
Hong Yang
Kungliga Tekniska Högskolan (KTH)
Mehtap Aydın
University of Health Sciences
Gizem Alkurt
University of Health Sciences
Woonghee Kim
Kungliga Tekniska Högskolan (KTH)
Dogukan Akyol
University of Health Sciences
C. Zhang
Zhengzhou University
Kungliga Tekniska Högskolan (KTH)
Gizem Dinler-Doganay
Istanbul Teknik Universitesi (ITÜ)
Hasan Turkez
Atatürk Üniversitesi
Saeed Shoaie
Kungliga Tekniska Högskolan (KTH)
King's College London
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
Jan Borén
Sahlgrenska universitetssjukhuset
Oktay Olmuscelik
Istanbul Medipol Universitesi
Levent Doganay
University of Health Sciences
Mathias Uhlen
Kungliga Tekniska Högskolan (KTH)
Adil Mardinoglu
King's College London
Kungliga Tekniska Högskolan (KTH)
Advanced Science
2198-3844 (ISSN) 21983844 (eISSN)
Vol. 8 17 2101222Ämneskategorier
Kirurgi
Gastroenterologi
Kardiologi
DOI
10.1002/advs.202101222
PubMed
34180141