Time-Resolved Thickness and Shape-Change Quantification using a Dual-Band Nanoplasmonic Ruler with Sub-Nanometer Resolution
Artikel i vetenskaplig tidskrift, 2022
Time-resolved measurements of changes in the size and shape of nanobiological objects and layers are crucial to understand their properties and optimize their performance. Optical sensing is particularly attractive with high throughput and sensitivity, and label-free operation. However, most state-of-the-art solutions require intricate modeling or multiparameter measurements to disentangle conformational or thickness changes of biomolecular layers from complex interfacial refractive index variations. Here, we present a dual-band nanoplasmonic ruler comprising mixed arrays of plasmonic nanoparticles with spectrally separated resonance peaks. As electrodynamic simulations and model experiments show, the ruler enables real-time simultaneous measurements of thickness and refractive index variations in uniform and heterogeneous layers with sub-nanometer resolution. Additionally, nanostructure shape changes can be tracked, as demonstrated by quantifying the degree of lipid vesicle deformation at the critical coverage prior to rupture and supported lipid bilayer formation. In a broader context, the presented nanofabrication approach constitutes a generic route for multimodal nanoplasmonic optical sensing.
supported lipid bilayer
nanorulers
biosensors
biomolecules
nanoplasmonic sensors
conformation
Författare
Ferry Nugroho
Universitas Indonesia
Chalmers, Fysik, Kemisk fysik
Vrije Universiteit Amsterdam
D. Switlik
Uniwersytet Warszawski
Antonius Armanious
Eidgenössische Technische Hochschule Zürich (ETH)
Padraic O'Reilly
Chalmers, Fysik, Kemisk fysik
Iwan Darmadi
Chalmers, Fysik, Kemisk fysik
Sara Nilsson
Chalmers, Fysik, Kemisk fysik
Vladimir Zhdanov
Russian Academy of Sciences
Chalmers, Fysik
Fredrik Höök
Chalmers, Fysik, Nano- och biofysik
Tomasz Antosiewicz
Chalmers, Fysik, Bionanofotonik
Uniwersytet Warszawski
Christoph Langhammer
Chalmers, Fysik, Kemisk fysik
ACS Nano
1936-0851 (ISSN) 1936-086X (eISSN)
Vol. 16 10 15814-15826Rambidrag inom utlysningen "Materials Science 2015"
Stiftelsen för Strategisk forskning (SSF) (RMA15-0052), 2016-05-01 -- 2021-06-30.
Ämneskategorier
Fysikalisk kemi
Atom- och molekylfysik och optik
Annan fysik
Infrastruktur
Chalmers materialanalyslaboratorium
DOI
10.1021/acsnano.2c04948
PubMed
36083800