Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
Artikel i vetenskaplig tidskrift, 2010
We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption.
electron
dependence
transfer
membrane
porphyrin
supramolecular
DNA
nanotechnology
construction
scaffold
bridge-acceptor systems
flow
orientation
fluorescence
dichroism
liposomes
membrane
photoinduced electron-transfer
Författare
Karl Börjesson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Joanna Wiberg
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Afaf El-Sagheer
University of Southampton
Suez Canal University
Thomas Ljungdahl
Göteborgs universitet
Jerker Mårtensson
Chalmers, Kemi- och bioteknik, Organisk kemi
T. Brown
University of Southampton
Bengt Nordén
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Bo Albinsson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
ACS Nano
1936-0851 (ISSN) 1936-086X (eISSN)
Vol. 4 9 5037-5046Styrkeområden
Nanovetenskap och nanoteknik
Energi
Livsvetenskaper och teknik (2010-2018)
Materialvetenskap
Ämneskategorier
Kemi
DOI
10.1021/nn100667b