Structure-function studies of enzymes cleaving covalent bonds between lignin and hemicelluloses
Research Project, 2016 – 2021

The cell wall provides both protection and structural support to plants. The mechanical strength of the cell wall stems from a complex network of different cell wall polymers – cellulose, different hemicelluloses, and lignin. During lignification of the cell wall, covalent bonds are formed between lignin and hemicelluloses, which restricts degradation, both for microorganisms and industrial processes. A type of enzyme able to cleave these lignin-hemicellulose bonds has recently been discovered, but to properly utilize the enzymes, detailed biochemical and structural information is necessary. In this project, we use biochemical methods in connection to X-ray crystallography to shed light on the enzyme action on the atom scale.  


Johan Larsbrink (contact)

Chalmers, Life Sciences, Industrial Biotechnology

Daniel Krska

Chalmers, Life Sciences, Industrial Biotechnology

Scott Mazurkewich

Chalmers, Life Sciences, Industrial Biotechnology

Andrea Seveso

Chalmers, Life Sciences, Industrial Biotechnology


University of Copenhagen

Köbenhavn, Denmark


Novo Nordisk Foundation

Project ID: NNF17OC0027698
Funding Chalmers participation during 2018–2020


Project ID: CTH-010
Funding Chalmers participation during 2017–2018


Project ID: CTH-003
Funding Chalmers participation during 2016–2017

Related Areas of Advance and Infrastructure

Sustainable development

Driving Forces


Areas of Advance

Life Science Engineering (2010-2018)

Areas of Advance

Materials Science

Areas of Advance


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