Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition
Journal article, 2021

During diffusion of nanoparticles bound to a cellular membrane by ligand-receptor pairs, the distance to the laterally mobile interface is sufficiently short for their motion to depend not only on the membrane-mediated diffusivity of the tethers but also in a not yet fully understood manner on nanoparticle size and interfacial hydrodynamics. By quantifying diffusivity, velocity, and size of individual membrane-bound liposomes subjected to a hydrodynamic shear flow, we have successfully separated the diffusivity contributions from particle size and number of tethers. The obtained diffusion-size relations for synthetic and extracellular lipid vesicles are not well-described by the conventional no-slip boundary condition, suggesting partial slip as well as a significant diffusivity dependence on the distance to the lipid bilayer. These insights, extending the understanding of diffusion of biological nanoparticles at lipid bilayers, are of relevance for processes such as cellular uptake of viruses and lipid nanoparticles or labeling of cell-membrane-residing molecules.

single-particle tracking

confined diffusion

Multivalent interactions

lipid vesicles

slip length

Author

Erik Olsén

Chalmers, Physics, Nano and Biophysics

Silver Jõemetsa

Chalmers, Physics, Nano and Biophysics

Adrian Gonzalez Rodriguez

Chalmers, Physics, Nano and Biophysics

Paul Joyce

University of South Australia

Chalmers, Physics, Biological Physics

Vladimir Zhdanov

Chalmers, Physics

Russian Academy of Sciences

Daniel Midtvedt

University of Gothenburg

Fredrik Höök

Chalmers, Physics, Nano and Biophysics

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. In Press

Subject Categories

Physical Chemistry

Food Engineering

Biophysics

DOI

10.1021/acs.nanolett.1c02092

PubMed

34403260

More information

Latest update

9/15/2021