Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition
Artikel i vetenskaplig tidskrift, 2021

During diffusion of nanoparticles bound to a cellular membrane by ligand-receptor pairs, the distance to the laterally mobile interface is sufficiently short for their motion to depend not only on the membrane-mediated diffusivity of the tethers but also in a not yet fully understood manner on nanoparticle size and interfacial hydrodynamics. By quantifying diffusivity, velocity, and size of individual membrane-bound liposomes subjected to a hydrodynamic shear flow, we have successfully separated the diffusivity contributions from particle size and number of tethers. The obtained diffusion-size relations for synthetic and extracellular lipid vesicles are not well-described by the conventional no-slip boundary condition, suggesting partial slip as well as a significant diffusivity dependence on the distance to the lipid bilayer. These insights, extending the understanding of diffusion of biological nanoparticles at lipid bilayers, are of relevance for processes such as cellular uptake of viruses and lipid nanoparticles or labeling of cell-membrane-residing molecules.

single-particle tracking

confined diffusion

Multivalent interactions

lipid vesicles

slip length

Författare

Erik Olsén

Chalmers, Fysik, Nano- och biofysik

Silver Jõemetsa

Chalmers, Fysik, Nano- och biofysik

Adrian Gonzalez Rodriguez

Chalmers, Fysik, Nano- och biofysik

Paul Joyce

University of South Australia

Chalmers, Fysik, Biologisk fysik

Vladimir Zhdanov

Chalmers, Fysik

Russian Academy of Sciences

Daniel Midtvedt

Göteborgs universitet

Fredrik Höök

Chalmers, Fysik, Nano- och biofysik

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. In Press

Ämneskategorier

Fysikalisk kemi

Livsmedelsteknik

Biofysik

DOI

10.1021/acs.nanolett.1c02092

Mer information

Senast uppdaterat

2021-09-15