Polysaccharide-based antibacterial coating technologies
Review article, 2023

To tackle antimicrobial resistance, a global threat identified by the United Nations, is a common cause of healthcare-associated infections (HAI) and is responsible for significant costs on healthcare systems, a substantial amount of research has been devoted to developing polysaccharide-based strategies that prevent bacterial attachment and biofilm formation on surfaces. Polysaccharides are essential building blocks for life and an abundant renewable resource that have attracted much attention due to their intrinsic remarkable biological potential antibacterial activities. If converted into efficient antibacterial coatings that could be applied to a broad range of surfaces and applications, polysaccharide-based coatings could have a significant potential global impact. However, the ultimate success of polysaccharide-based antibacterial materials will be determined by their potential for use in manufacturing processes that are scalable, versatile, and affordable. Therefore, in this review we focus on recent advances in polysaccharide-based antibacterial coatings from the perspective of fabrication methods. We first provide an overview of strategies for designing polysaccharide-based antimicrobial formulations and methods to assess the antibacterial properties of coatings. Recent advances on manufacturing polysaccharide-based coatings using some of the most common polysaccharides and fabrication methods are then detailed, followed by a critical comparative overview of associated challenges and opportunities for future developments. Statement of significance: Our review presents a timely perspective by being the first review in the field to focus on advances on polysaccharide-based antibacterial coatings from the perspective of fabrication methods along with an overview of strategies for designing polysaccharide-based antimicrobial formulations, methods to assess the antibacterial properties of coatings as well as a critical comparative overview of associated challenges and opportunities for future developments. Meanwhile this work is specifically targeted at an audience focused on featuring critical information and guidelines for developing polysaccharide-based coatings. Including such a complementary work in the journal could lead to further developments on polysaccharide antibacterial applications.

Antibacterial testing

Coating technology

Antibacterial coatings

Polysaccharides

Author

Hengzhi Ruan

Chalmers, Industrial and Materials Science, Engineering Materials

Alexandra Aulova

Chalmers, Industrial and Materials Science, Engineering Materials

Viney Ghai

Chalmers, Industrial and Materials Science, Engineering Materials

2D-Tech

Santosh Pandit

Chalmers, Life Sciences, Systems and Synthetic Biology

2D-Tech

Martin Lovmar

Wellspect Healthcare

Chalmers, Life Sciences, Systems and Synthetic Biology

Ivan Mijakovic

Novo Nordisk Foundation

2D-Tech

Chalmers, Life Sciences, Systems and Synthetic Biology

Roland Kádár

2D-Tech

Chalmers, Industrial and Materials Science, Engineering Materials

Acta Biomaterialia

1742-7061 (ISSN) 18787568 (eISSN)

Vol. 168 42-77

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Subject Categories

Polymer Chemistry

Biochemistry and Molecular Biology

Medical Engineering

Manufacturing, Surface and Joining Technology

Bio Materials

Microbiology

Organic Chemistry

Driving Forces

Sustainable development

Areas of Advance

Health Engineering

Life Science Engineering (2010-2018)

Materials Science

DOI

10.1016/j.actbio.2023.07.023

PubMed

37481193

More information

Latest update

2/29/2024