Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications
Journal article, 2023

A facile novel approach of introducing dopamine and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide via dopamine-triggered in situ synthesis into gelatin hydrogels in the presence of ZnSO4 is presented in this study. Remarkably, the resulting hydrogels showed 99.99 and 100% antibacterial efficiency against Gram-positive and Gram-negative bacteria, respectively, making them the highest performing surfaces in their class. Furthermore, the hydrogels showed adhesive properties, self-healing ability, antifreeze properties, electrical conductivity, fatigue resistance, and mechanical stability from −100 to 80 °C. The added multifunctional performance overcomes several disadvantages of gelatin-based hydrogels such as poor mechanical properties and limited thermostability. Overall, the newly developed hydrogels show significant potential for numerous biomedical applications, such as wearable monitoring sensors and antibacterial coatings.

hydrogel coating

gelatin

biomimetic strategy

antibacterial materials

Author

Hengzhi Ruan

Chalmers, Industrial and Materials Science, Engineering Materials

Marko Bek

Chalmers, Industrial and Materials Science, Engineering Materials

Santosh Pandit

Chalmers, Life Sciences, Systems and Synthetic Biology

Alexandra Aulova

Chalmers, Industrial and Materials Science, Engineering Materials

Jian Zhang

Chalmers, Life Sciences, Systems and Synthetic Biology

Philip Bjellheim

Wellspect Healthcare

Martin Lovmar

Chalmers, Life Sciences, Systems and Synthetic Biology

Ivan Mijakovic

Chalmers, Life Sciences, Systems and Synthetic Biology

Roland Kádár

Chalmers, Industrial and Materials Science, Engineering Materials

ACS Applied Materials & Interfaces

1944-8244 (ISSN) 1944-8252 (eISSN)

Vol. 15 47 54249-54249–54265

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Subject Categories

Polymer Chemistry

Physical Sciences

Biological Sciences

Materials Chemistry

Other Chemistry Topics

Driving Forces

Sustainable development

Areas of Advance

Life Science Engineering (2010-2018)

Materials Science

Infrastructure

Chalmers Materials Analysis Laboratory

DOI

10.1021/acsami.3c10477

PubMed

37975260

More information

Latest update

12/15/2023