Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
Journal article, 2021

Allergic diseases are the most common chronic diseases in childrenin the Western world, but little is know about what factors influence immune maturation and allergy development. We therefore aimed to associate infant and maternal metabolomes to T- and B-cell subpopulations and allergy diagnosis. We performed liquid chromatography-mass spectrometry based untargeted metabolomics on blood plasma from mothers (third trimester, n = 605; delivery, n = 558) and from the umbilical cord (n = 366). The measured metabolomes were associated to T- and B-cell subpopulations up to 4 months after delivery and to doctor´s diagnosed eczema, food allergy and asthma at one year of age using random forest analysis. Maternal and cord plasma at delivery could predict the number of CD24+CD38low memory B-cells (p = 0.033, n = 26 and p = 0.009, n = 22), but future allergy status could not be distinguished from any of the three measured metabolomes. Replication of previous literature findings showed hypoxanthine to be upregulated in the umbilical cord of children with subsequent asthma. This exploratory study suggests foetal immune programming occuring during pregnancy as the metabolomic profiles of mothers and infants at delivery related to infants’ B-cell maturation.

Author

Olle Hartvigsson

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Malin Barman

Karolinska Institutet

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Hardis Rabe

University of Gothenburg

Anna Sandin

Umeå University

A. E. Wold

University of Gothenburg

Carl Brunius

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Scientific Reports

2045-2322 (ISSN)

Vol. 11 1 12706

Early life nutrition and immune development with focus on allergy prevention

Swedish Research Council (VR) (2013-3154), 2014-01-01 -- 2018-12-31.

Ett systemtoxikologibaserat angreppssätt för bedömning av kombinationseffekter av toxiska metaller tidigt i livet

Formas (2018-02275), 2018-12-01 -- 2022-11-30.

Subject Categories

Pediatrics

Immunology

Respiratory Medicine and Allergy

DOI

10.1038/s41598-021-92239-3

PubMed

34135462

More information

Latest update

6/30/2021