An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Journal article, 2022
Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.
Author
Elise Nordin
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Stine K. Steffensen
Aarhus University
Bente B. Laursen
Aarhus University
Sven Olof Andersson
Örebro University
Jan Erik Johansson
Örebro University
Per Åman
Swedish University of Agricultural Sciences (SLU)
Göran Hallmans
Umeå University
Michael Borre
Arhus Universitetshospital
Dan Stærk
University of Copenhagen
Kati Hanhineva
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
University of Eastern Finland
Inge S. Fomsgaard
Aarhus University
Rikard Landberg
Umeå University
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Scientific Reports
2045-2322 (ISSN) 20452322 (eISSN)
Vol. 12 1 5260Subject Categories
Urology and Nephrology
Medicinal Chemistry
Nutrition and Dietetics
DOI
10.1038/s41598-022-08856-z
PubMed
35347164