An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Artikel i vetenskaplig tidskrift, 2022

Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.


Elise Nordin

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Stine K. Steffensen

Aarhus Universitet

Bente B. Laursen

Aarhus Universitet

Sven Olof Andersson

Örebro universitet

Jan Erik Johansson

Örebro universitet

Per Åman

Sveriges lantbruksuniversitet (SLU)

Göran Hallmans

Umeå universitet

Michael Borre

Arhus Universitetshospital

Dan Stærk

Köpenhamns universitet

Kati Hanhineva

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Itä-Suomen Yliopisto

Inge S. Fomsgaard

Aarhus Universitet

Rikard Landberg

Umeå universitet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Scientific Reports

2045-2322 (ISSN) 20452322 (eISSN)

Vol. 12 1 5260


Urologi och njurmedicin







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