In situ synthesis of conductive polypyrrole on electrospun cellulose nanofibers: scaffold for neural tissue engineering
Artikel i vetenskaplig tidskrift, 2015

This study reports the synthesis of conductive polypyrrole (PPy) on electrospun cellulose nanofibers. The cellulose nanofibers were electrospun via cellulose acetate and surface modified using in situ pyrrole polymerization. PPy adhered to the cellulose nanofiber surface as small particles and caused a 105 fold increase in conductivity compared to unmodified cellulose nanofibers. In addition, tests revealed no cytotoxic potential for the PPy coated cellulose nanofiber materials. In vitro culturing using SH-SY5Y human neuroblastoma cells indicated enhanced cell adhesion on the PPy coated cellulose material. SH-SY5Y cell viability was evident up to 15 days of differentiation and cells adhered to the PPy coated cellulose nanofibers and altered their morphology to a more neuron like phenotype.

Tissue engineering

Polypyrrole

Fiber

Cellulose

Electrospinning

Författare

Johannes Thunberg

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Theodoros Kalogeropoulos

Chalmers University of Technology

Volodymyr Kuzmenko

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Daniel Hägg

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Polymerteknologi

Sara Johannesson

Chalmers University of Technology

Gunnar Westman

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Paul Gatenholm

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Polymerteknologi

Cellulose

0969-0239 (ISSN)

Vol. 22 1459-1467

Ämneskategorier

Textil-, gummi- och polymermaterial

Styrkeområden

Materialvetenskap

DOI

10.1007/s10570-015-0591-5