Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids – Role of oil origin, added tocopherols and lipolytic activity
Artikel i vetenskaplig tidskrift, 2019

The formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE) in cod liver-, anchovy-, krill-, and algae oil during in vitro digestion with human gastrointestinal fluids was investigated. Adding rabbit gastric lipase, lipase inhibitor (orlistat) and tocopherols to cod liver oil, lipolysis and oxidation was also studied. Among the marine oils, the highest aldehyde levels (18 µM MDA, 3 µM HHE and 0.2 µM HNE) were detected after digestion of cod liver oil, while the lowest levels were detected in krill and algae oils. Addition of rabbit gastric lipase significantly increased the release of HNE during the digestion. Orlistat significantly reduced lipolysis and MDA formation. Formation of MDA and HHE was delayed by tocopherols, the tocopherol mix Covi-ox® T 70 EU being more effective than pure α-tocopherol.

Tocopherol

Lipolysis

Human gastrointestinal enzymes

Lipase inhibitor

Lipid oxidation

Rabbit gastric lipase

Aldehydes

Marine oils

Författare

Cecilia Tullberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

G. E. Vegarud

Norges miljø- og biovitenskapelige universitet

Ingrid Undeland

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Food Chemistry

0308-8146 (ISSN)

Vol. 270 527-537

Gastrointestinal oxidation - ett oönskat hinder för optimala hälsoeffekter från våra värdefulla omega-3-fettsyror

Formas, 2013-01-01 -- 2015-12-31.

Ämneskategorier

Annan geovetenskap och miljövetenskap

Annan medicinsk grundvetenskap

Farmakologi och toxikologi

DOI

10.1016/j.foodchem.2018.07.049

Mer information

Senast uppdaterat

2018-08-30