Strategies and challenges for metabolic rewiring
Reviewartikel, 2019

Metabolic engineering is often centred on rewiring cellular metabolism to improve the production of chemicals. Turning cells into efficient factories is challenging because of ubiquitous and tightly regulated metabolic interactions. Tools and strategies from different disciplines, including systems biology, synthetic biology and evolutionary engineering, have been integrated into metabolic engineering to overcome challenges with rewiring metabolism for cell factory development. In this review, we summarise the recent development of tools and strategies for dynamic pathway regulation, compartmentalisation, modular and evolutionary engineering. In addition, we describe how systems biology tools benefit metabolic rewiring for advancing the development of cell factories.

Metabolic rewiring

Metabolism

Evolutionary engineering

Systems biology

Metabolic engineering

Rational engineering

Författare

Tao Yu

Chalmers, Biologi och bioteknik, Systembiologi

Yasaman Dabirian

Chalmers, Biologi och bioteknik, Systembiologi

Quanli Liu

Chalmers, Biologi och bioteknik, Systembiologi

Verena Siewers

Chalmers, Biologi och bioteknik, Systembiologi

Jens Christian Froslev Nielsen

Danmarks Tekniske Universitet (DTU)

Chalmers, Biologi och bioteknik, Systembiologi

Current Opinion in Systems Biology

24523100 (eISSN)

Vol. 15 30-38

Ämneskategorier

Annan maskinteknik

Programvaruteknik

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

DOI

10.1016/j.coisb.2019.03.004

Mer information

Senast uppdaterat

2019-11-19