Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer
Inledande text i tidskrift, 2019

Background & aims: Rye consumption has shown beneficial effects on prostate cancer tumors, as indicated by slower initial tumor growth in animal models and lowering of prostate-specific antigen (PSA) in humans. This study evaluated the effects of whole grain/bran rye consumption on low-grade inflammation and endothelial function biomarkers in men with prostate cancer. Methods: Seventeen men with untreated, low-grade prostate cancer consumed 485 g rye whole grain and bran products (RP) per day or refined wheat products with added cellulose (WP) in a randomized crossover design. Fasting blood samples were taken before and after 2, 4, and 6 weeks of treatment. Results: Concentrations of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). Cathepsin S concentration was positively correlated to TNF-R2 and endostatin concentrations across all occasions. Strong correlations were consistently found between intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and between interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1RA). No effect of intervention was found in 92 inflammation-related protein biomarkers measured in a proximity extension assay. Conclusions: RP diet lowered TNF-R2, e-selectin, and endostatin, compared with WP in men with prostate cancer. These effects were accompanied by a reduction in PSA.

Whole grain/bran rye

Prostate cancer

Plasma

Endothelial function markers

Low-grade inflammatory markers

Refined wheat

Författare

Galia Zamaratskaia

Sveriges lantbruksuniversitet (SLU)

Nor Adila Mhd Omar

Karolinska Institutet

Carl Brunius

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Sveriges lantbruksuniversitet (SLU)

Göran Hallmans

Umeå universitet

Jan Erik Johansson

Örebro universitet

Sven Olof Andersson

Örebro universitet

Anders Larsson

Akademiska Sjukhuset

Per Åman

Sveriges lantbruksuniversitet (SLU)

Rikard Landberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Karolinska Institutet

Umeå universitet

Clinical Nutrition

0261-5614 (ISSN)

Vol. In press

Ämneskategorier

Urologi och njurmedicin

Läkemedelskemi

Cancer och onkologi

DOI

10.1016/j.clnu.2019.01.007

Mer information

Senast uppdaterat

2019-11-19