Evaluating accessibility, usability and interoperability of genome-scale metabolic models for diverse yeasts species
Reviewartikel, 2021

Metabolic network reconstructions have become an important tool for probing cellular metabolism in the field of systems biology. They are used as tools for quantitative prediction but also as scaffolds for further knowledge contextualization. The yeast Saccharomyces cerevisiae was one of the first organisms for which a genome-scale metabolic model (GEM) was reconstructed, in 2003, and since then 45 metabolic models have been developed for a wide variety of relevant yeasts species. A systematic evaluation of these models revealed that-despite this long modeling history-the sequential process of tracing model files, setting them up for basic simulation purposes and comparing them across species and even different versions, is still not a generalizable task. These findings call the yeast modeling community to comply to standard practices on model development and sharing in order to make GEMs accessible and useful for a wider public.

yeast species

systems biology




genome-scale metabolic models


Iván Domenzain Del Castillo Cerecer

Chalmers, Biologi och bioteknik, Systembiologi

Feiran Li

Chalmers, Biologi och bioteknik, Systembiologi

Eduard Kerkhoven

Chalmers, Biologi och bioteknik, Systembiologi

Verena Siewers

Chalmers, Biologi och bioteknik, Systembiologi

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 21 1 foab002


Annan data- och informationsvetenskap

Bioinformatik (beräkningsbiologi)






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