Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies
Artikel i vetenskaplig tidskrift, 2024

Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.

smoking

diet

physical activity

Translation to population health

metabolome

mortality

metabolomics

longevity

alcohol

lifestyle

BMI

Författare

Anne Julie Tessier

Harvard School of Public Health

Fenglei Wang

Harvard School of Public Health

Liming Liang

Harvard School of Public Health

Clemens Wittenbecher

Chalmers, Life sciences, Livsmedelsvetenskap

Danielle E. Haslam

Harvard School of Public Health

Brigham and Women's Hospital

A. Heather Eliassen

Harvard School of Public Health

Brigham and Women's Hospital

Deirdre K. Tobias

Harvard School of Public Health

Brigham and Women's Hospital

Jun Li

Brigham and Women's Hospital

Harvard School of Public Health

Oana Zeleznik

Brigham and Women's Hospital

Alberto Ascherio

Brigham and Women's Hospital

Harvard School of Public Health

Qi Sun

Harvard School of Public Health

Brigham and Women's Hospital

Meir J. Stampfer

Brigham and Women's Hospital

Harvard School of Public Health

Francine Grodstein

Rush University Medical Center

Harvard School of Public Health

Kathryn Rexrode

Brigham and Women's Hospital

Jo Ann E. Manson

Brigham and Women's Hospital

Harvard School of Public Health

Raji Balasubramanian

University of Massachusetts

Clary B. Clish

Broad Institute

Miguel A. Martínez-González

Universidad de Navarra

Harvard School of Public Health

Jorge E. Chavarro

Harvard School of Public Health

Brigham and Women's Hospital

Frank B. Hu

Harvard School of Public Health

Brigham and Women's Hospital

Marta Guasch-Ferré

Harvard School of Public Health

Novo Nordisk Fonden

Med

26666359 (ISSN) 26666340 (eISSN)

Vol. 5 3 224-238.e5

Ämneskategorier

Kardiologi

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Näringslära

DOI

10.1016/j.medj.2024.01.010

PubMed

38366602

Mer information

Senast uppdaterat

2024-03-14