Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies
Artikel i vetenskaplig tidskrift, 2024
Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.
alcohol
longevity
mortality
BMI
lifestyle
metabolomics
smoking
physical activity
metabolome
Translation to population health
diet
Författare
Anne Julie Tessier
Harvard University
Fenglei Wang
Harvard University
Liming Liang
Harvard University
Clemens Wittenbecher
Chalmers, Life sciences, Livsmedelsvetenskap
Danielle E. Haslam
Brigham and Women's Hospital
Harvard University
A. Heather Eliassen
Harvard University
Brigham and Women's Hospital
Deirdre K. Tobias
Harvard University
Brigham and Women's Hospital
Jun Li
Brigham and Women's Hospital
Harvard University
Oana Zeleznik
Brigham and Women's Hospital
Alberto Ascherio
Brigham and Women's Hospital
Harvard University
Qi Sun
Harvard University
Brigham and Women's Hospital
Meir J. Stampfer
Harvard University
Brigham and Women's Hospital
Francine Grodstein
Harvard University
Rush University Medical Center
Kathryn Rexrode
Brigham and Women's Hospital
Jo Ann E. Manson
Brigham and Women's Hospital
Harvard University
Raji Balasubramanian
University of Massachusetts
Clary B. Clish
Broad Institute
Miguel A. Martínez-González
Universidad de Navarra
Harvard University
Jorge E. Chavarro
Brigham and Women's Hospital
Harvard University
Frank B. Hu
Harvard University
Brigham and Women's Hospital
Marta Guasch-Ferré
Novo Nordisk Fonden
Harvard University
Med
26666359 (ISSN) 26666340 (eISSN)
Vol. 5 3 224-238.e5Ämneskategorier (SSIF 2011)
Kardiologi
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Näringslära
DOI
10.1016/j.medj.2024.01.010
PubMed
38366602