Extensively acquired antimicrobial-resistant bacteria restructure the individual microbial community in post-antibiotic conditions
Artikel i vetenskaplig tidskrift, 2025
In recent years, the overuse of antibiotics has led to the emergence of antimicrobial-resistant (AMR) bacteria. To evaluate the spread of AMR bacteria, the reservoir of AMR genes (resistome) has been identified in environmental samples, hospital environments, and human populations, but the functional role of AMR bacteria and their persistence within individuals has not been fully investigated. Here, we performed a strain-resolved in-depth analysis of the resistome changes by reconstructing a large number of metagenome-assembled genomes from the gut microbiome of an antibiotic-treated individual. Interestingly, we identified two bacterial populations with different resistome profiles: extensively acquired antimicrobial-resistant bacteria (EARB) and sporadically acquired antimicrobial-resistant bacteria, and found that EARB showed broader drug resistance and a significant functional role in shaping individual microbiome composition after antibiotic treatment. Our findings of AMR bacteria would provide a new avenue for controlling the spread of AMR bacteria in the human community.
Författare
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Gwangju Institute of Science and Technology
[Person fec5101b-1f61-406b-9559-261a4b021c1f not found]
Gwangju Institute of Science and Technology
[Person d196f524-df2b-4c5a-b357-0182e44ca8e5 not found]
Gwangju Institute of Science and Technology
[Person eec9cd55-0b53-4dfc-bb64-963c257c8371 not found]
Gwangju Institute of Science and Technology
[Person 32de4a4a-44cd-4e90-90a5-631afdb7c8fa not found]
Gwangju Institute of Science and Technology
[Person 30a8e961-dab2-4813-ad39-14e13c34ac44 not found]
BioInnovation Institute
Chalmers, Life sciences, Systembiologi
[Person 2d3045ed-d679-4faa-b7c8-f9ef324e218a not found]
King's College London
Kungliga Tekniska Högskolan (KTH)
[Person 63015dc1-acd3-436a-9712-683a2492dc82 not found]
King's College London
[Person 5839e467-2855-4ef2-8d48-d478f1423d4f not found]
Gwangju Institute of Science and Technology
[Person 07e8f3c2-3de5-4a05-b5a6-a6189944c7e7 not found]
The Catholic University of Korea, College of Medicine
[Person aec8fc12-8258-45d3-a93d-9e08829403d1 not found]
Pohang University of Science and Technology
[Person d8e9ebcf-c485-4607-b881-de4ebccf1073 not found]
Gwangju Institute of Science and Technology
npj Biofilms and Microbiomes
20555008 (eISSN)
Vol. 11 1 78Ämneskategorier (SSIF 2025)
Folkhälsovetenskap, global hälsa och socialmedicin
Infektionsmedicin
Mikrobiologi
DOI
10.1038/s41522-025-00705-x
PubMed
40360555
Relaterade dataset
EARB Project [dataset]
URI: https://figshare.com/projects/EARB_Project/193070