Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Artikel i vetenskaplig tidskrift, 2014
Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Nuclear Translocation
Yeast Physiology
Glucose Metabolism
AMP-activated Kinase (AMPK)
Dynamic Control
Signal Transduction
Författare
Loubna Bendrioua
Göteborgs universitet
Maria Smedh
Göteborgs universitet
Joachim Almquist
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Marija Cvijovic
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematik
Mats Jirstrand
Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik
Mattias Goksör
Göteborgs universitet
Caroline B. Adiels
Göteborgs universitet
Stefan Hohmann
Göteborgs universitet
Journal of Biological Chemistry
0021-9258 (ISSN) 1083-351X (eISSN)
Vol. 289 18 12863-12875Ämneskategorier
Biokemi och molekylärbiologi
DOI
10.1074/jbc.M114.547976