Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Journal article, 2014
Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Nuclear Translocation
Yeast Physiology
Glucose Metabolism
AMP-activated Kinase (AMPK)
Dynamic Control
Signal Transduction
Author
Loubna Bendrioua
University of Gothenburg
Maria Smedh
University of Gothenburg
Joachim Almquist
Chalmers, Chemical and Biological Engineering, Life Sciences
Marija Cvijovic
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematics
Mats Jirstrand
Fraunhofer-Chalmers Centre
Mattias Goksör
University of Gothenburg
Caroline B. Adiels
University of Gothenburg
Stefan Hohmann
University of Gothenburg
Journal of Biological Chemistry
0021-9258 (ISSN) 1083-351X (eISSN)
Vol. 289 18 12863-12875Subject Categories
Biochemistry and Molecular Biology
DOI
10.1074/jbc.M114.547976