Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Journal article, 2014

Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Yeast Physiology

Dynamic Control

Nuclear Translocation

AMP-activated Kinase (AMPK)

Signal Transduction

Glucose Metabolism

Author

Loubna Bendrioua

University of Gothenburg

Maria Smedh

University of Gothenburg

Joachim Almquist

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Marija Cvijovic

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematics

Mats Jirstrand

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Mattias Goksör

University of Gothenburg

Caroline B. Adiels

University of Gothenburg

Stefan Hohmann

University of Gothenburg

Journal of Biological Chemistry

0021-9258 (ISSN) 1083-351X (eISSN)

Vol. 289 18 12863-12875

Subject Categories

Biochemistry and Molecular Biology

DOI

10.1074/jbc.M114.547976

More information

Created

10/7/2017