Karolin Frykholm

Researcher at Chemical Biology

I am a researcher in the research group of Professor Fredrik Westerlund, where we are using nanochannels and fluorescence microscopy to study DNA at the single molecule level. Using methods developed in the group we can map long sequences of DNA and use this information for bacterial typing or plasmid identification. We can also detect specific genes, such as antibiotic resistance genes, carried by the plasmids.

Source: chalmers.se

Contact Details

Publications (27)
Projects (0)

Showing 27 publications

2023

Strain-level bacterial typing directly from patient samples using optical DNA mapping

My Nyblom, Anna Johnning, Karolin Frykholm et al

COMMUNICATIONS MEDICINE. Vol. 3 (31)

Journal article

2022

DNA in Nanochannels - Theory and Applications

Karolin Frykholm, Vilhelm Müller, Sriram Kesarimangalam et al

Quarterly Reviews of Biophysics. Vol. 55

Review article

2021

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

Albertas Dvirnas, Callum L. Stewart, Vilhelm Müller et al

PLoS ONE. Vol. 16 (11 November)

Journal article

2021

Polyphasic characterization of carbapenemresistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3gene

Catarina Ferreira, Santosh Kumar Bikarolla, Karolin Frykholm et al

PLoS ONE. Vol. 16 (2 Febuary)

Journal article

2019

Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

Catarina Ferreira, D. Bogas, Santosh K. Bikarolla et al

Chemosphere. Vol. 220, p. 748-759

Journal article

2018

Hairpins in the conformations of a confined polymer

E. Werner, A. Jain, A. Muralidhar et al

Biomicrofluidics. Vol. 12 (2)

Journal article

2017

Exploring DNA-protein interactions on the single DNA molecule level using nanofluidic tools

Karolin Frykholm, Lena Nyberg, Fredrik Westerlund

Integrative Biology (United Kingdom). Vol. 9 (8), p. 650-661

Journal article

2016

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

Karolin Frykholm, Ronnie Berntsson, M. Claesson et al

Nucleic Acids Research. Vol. 44 (15), p. 7219-7227

Journal article

2016

Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels

Louise Fornander, Karolin Frykholm, Joachim Fritzsche et al

Langmuir. Vol. 32 (33), p. 8403-8412

Journal article

2016

Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Vilhelm Müller, Fredrika Rajer, Karolin Frykholm et al

Scientific Reports. Vol. 6, p. 37938-

Journal article

2015

Using nanofluidic channels to probe dynamics of RAD51-Filaments

Louise Fornander, Mohammadreza Alizadehheidari, E. Werner et al

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, p. 1826-1828

Paper in proceeding

2015

Fast size-determination of intact bacterial plasmids using nanofluidic channels

Karolin Frykholm, Lena Nyberg, E. Lagerstedt et al

Lab on a Chip - Miniaturisation for Chemistry and Biology. Vol. 15 (13), p. 2739-2743

Journal article

2014

Probing Physical Properties of a DNA- Protein Complex Using Nanofluidic Channels

Karolin Frykholm, Mohammadreza Alizadehheidari, Joachim Fritzsche et al

Small. Vol. 10 (5), p. 884-887

Journal article

2014

Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments

Louise Fornander, F. Persson, Joachim Fritzsche et al

Biophysical Journal. Vol. 106 (2), p. 692A-693A

Magazine article

2014

Sensing Conformational Changes in DNA upon Ligand Binding Using QCM-D. Polyamine Condensation and Rad51 Extension of DNA Layers

Lu Sun, Karolin Frykholm, Louise Fornander et al

Journal of Physical Chemistry B. Vol. 118 (41), p. 11895-11904

Journal article

2013

Probing the Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels

Mohammadreza Alizadehheidari, Karolin Frykholm, Joachim Fritzsche et al

European Biophysics Journal. Vol. 42, p. S134-S134

Magazine article

2013

Probing concentration-dependent behavior of DNA-binding proteins on a single-molecule level illustrated by Rad51

Karolin Frykholm, Camilla Freitag, Fredrik Persson et al

Analytical Biochemistry. Vol. 443 (2), p. 261-268

Journal article

2013

Probing physical properties of DNA-protein complexes using nanofluidic channels

Karolin Frykholm, Mohammadreza Alizadehheidari, Louise Fornander et al

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Freiburg; Germany; 27 October 2013 through 31 October 2013. Vol. 2, p. 1311-1313

Paper in proceeding

2012

Ca2+ improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination

Louise Fornander, Karolin Frykholm, Anna Reymer et al

Nucleic Acids Research. Vol. 40 (11), p. 4904-4913

Journal article

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2010

DNA strand exchange catalyzed by molecular crowding in PEG solutions

Bobo Feng, Karolin Frykholm, Bengt Nordén et al

Chemical Communications. Vol. 46 (43), p. 8231-8233

Journal article