Karolin Frykholm

Researcher at Chemical Biology

I am a researcher in the research group of Professor Fredrik Westerlund, where we are using nanochannels and fluorescence microscopy to study DNA at the single molecule level. Using methods developed in the group we can map long sequences of DNA and use this information for bacterial typing or plasmid identification. We can also detect specific genes, such as antibiotic resistance genes, carried by the plasmids.

Source: chalmers.se
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Showing 27 publications


Strain-level bacterial typing directly from patient samples using optical DNA mapping

My Nyblom, Anna Johnning, Karolin Frykholm et al
Journal article

DNA in Nanochannels - Theory and Applications

Karolin Frykholm, Vilhelm Müller, Sriram Kesarimangalam et al
Quarterly Reviews of Biophysics. Vol. 55
Review article

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

Albertas Dvirnas, Callum L. Stewart, Vilhelm Müller et al
PLoS ONE. Vol. 16 (11 November)
Journal article

Polyphasic characterization of carbapenemresistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3gene

Catarina Ferreira, Santosh Kumar Bikarolla, Karolin Frykholm et al
PLoS ONE. Vol. 16 (2 Febuary)
Journal article

Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

Catarina Ferreira, D. Bogas, Santosh K. Bikarolla et al
Chemosphere. Vol. 220, p. 748-759
Journal article

Hairpins in the conformations of a confined polymer

E. Werner, A. Jain, A. Muralidhar et al
Biomicrofluidics. Vol. 12 (2)
Journal article

Exploring DNA-protein interactions on the single DNA molecule level using nanofluidic tools

Karolin Frykholm, Lena Nyberg, Fredrik Westerlund
Integrative Biology (United Kingdom). Vol. 9 (8), p. 650-661
Journal article

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

Karolin Frykholm, Ronnie Berntsson, M. Claesson et al
Nucleic Acids Research. Vol. 44 (15), p. 7219-7227
Journal article

Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels

Louise Fornander, Karolin Frykholm, Joachim Fritzsche et al
Langmuir. Vol. 32 (33), p. 8403-8412
Journal article

Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Vilhelm Müller, Fredrika Rajer, Karolin Frykholm et al
Scientific Reports. Vol. 6, p. 37938-
Journal article

Using nanofluidic channels to probe dynamics of RAD51-Filaments

Louise Fornander, Mohammadreza Alizadehheidari, E. Werner et al
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, p. 1826-1828
Paper in proceeding

Fast size-determination of intact bacterial plasmids using nanofluidic channels

Karolin Frykholm, Lena Nyberg, E. Lagerstedt et al
Lab on a Chip - Miniaturisation for Chemistry and Biology. Vol. 15 (13), p. 2739-2743
Journal article

Probing Physical Properties of a DNA- Protein Complex Using Nanofluidic Channels

Karolin Frykholm, Mohammadreza Alizadehheidari, Joachim Fritzsche et al
Small. Vol. 10 (5), p. 884-887
Journal article

Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments

Louise Fornander, F. Persson, Joachim Fritzsche et al
Biophysical Journal. Vol. 106 (2), p. 692A-693A
Magazine article

Sensing Conformational Changes in DNA upon Ligand Binding Using QCM-D. Polyamine Condensation and Rad51 Extension of DNA Layers

Lu Sun, Karolin Frykholm, Louise Fornander et al
Journal of Physical Chemistry B. Vol. 118 (41), p. 11895-11904
Journal article

Probing the Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels

Mohammadreza Alizadehheidari, Karolin Frykholm, Joachim Fritzsche et al
European Biophysics Journal. Vol. 42, p. S134-S134
Magazine article

Probing concentration-dependent behavior of DNA-binding proteins on a single-molecule level illustrated by Rad51

Karolin Frykholm, Camilla Freitag, Fredrik Persson et al
Analytical Biochemistry. Vol. 443 (2), p. 261-268
Journal article

Probing physical properties of DNA-protein complexes using nanofluidic channels

Karolin Frykholm, Mohammadreza Alizadehheidari, Louise Fornander et al
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Freiburg; Germany; 27 October 2013 through 31 October 2013. Vol. 2, p. 1311-1313
Paper in proceeding

Ca2+ improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination

Louise Fornander, Karolin Frykholm, Anna Reymer et al
Nucleic Acids Research. Vol. 40 (11), p. 4904-4913
Journal article

DNA strand exchange catalyzed by molecular crowding in PEG solutions

Bobo Feng, Karolin Frykholm, Bengt Nordén et al
Chemical Communications. Vol. 46 (43), p. 8231-8233
Journal article

Mechanism of DNA Strand Exchange at Liposome Surfaces Investigated Using Mismatched DNA

Karolin Frykholm, Bengt Nordén, Fredrik Westerlund
Langmuir. Vol. 25 (3), p. 1606-1611
Journal article

Structure of human Rad51 protein filament from molecular modeling and site-specific linear dichroism spectroscopy

Anna Reymer, Karolin Frykholm, K. Morimatsu et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 106 (32), p. 13248-13253
Journal article

Enhanced DNA strand exchange on positively charged liposomes

Karolin Frykholm, Francesca Baldelli Bombelli, Bengt Nordén et al
Soft Matter (4), p. 2500 - 2506
Journal article

Adenovirus type 5 fiber knob domain has a critical role in fiber protein synthesis and encapsidation

Petra Henning, Emma Lundgren, Mattias Carlsson et al
Journal of General Virology. Vol. 87, p. 3151-3160
Journal article

Conserved conformation of RecA protein after executing the DNA strand-exchange reaction. A site-specific linear dichroism structure study

Karolin Frykholm, K. Morimatsu, Bengt Nordén
Biochemistry. Vol. 45 (37), p. 11172-11178
Journal article

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