Stem Cell Growth and Migration on Nanofibrous Polymer Scaffolds and Micro-Fluidic Channels on Silicon-Chip
Paper in proceedings, 2009

Stem cell growth and migration on nanofibrous scaffolds and micro-fluidic channels on Silicon-Chip were studied by using neural stem cells isolated from adult rats' brain. Electrospinning and lithographic technique were used for developing nanofibrous-polylactic acid (PLA) and polyurethane (PU) based-scaffolds and micro-fluidic channels on Si-Chips respectively. Immunocytochemical and morphological analysis showed better cell-matrix interaction with profound adhesion, proliferation and migration on the developed scaffolds. Cell culture assay with microfluidic channel revealed the ability of developed channel system in guiding neuronal stem cell growth towards specified directions. These studies extend the possibility of using developed nanofibrous scaffolds and micro-fluidic channel system for future electrical signal transmission based on living neural stem cells.

Author

Johan Liu

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Hans-Georg Kuhn

University of Gothenburg

Jing Yujia

Chalmers

East China University of Science and Technology

Jan-Olof Dahlberg

Chalmers

Linnea Ericsson

Chalmers

Anna Nilsson

Chalmers

Lena Nyberg

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Behroz Ohady

Chalmers

Johan Svensson

Chalmers

Björn Carlberg

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Christiana M. Cooper-Kuhn

University of Gothenburg

Teng Wang

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Yihua Zhu

East China University of Science and Technology

Proceedings of the 2009 Electronic Components and Technology Conference

0569-5503 (ISSN)

1080-1085

Subject Categories

Dentistry

DOI

10.1109/ECTC.2009.5074146

ISBN

9781424444762

More information

Latest update

12/7/2018