Stem Cell Growth and Migration on Nanofibrous Polymer Scaffolds and Micro-Fluidic Channels on Silicon-Chip
Paper in proceeding, 2009
Stem cell growth and migration on nanofibrous scaffolds and micro-fluidic channels on Silicon-Chip were studied by using neural stem cells isolated from adult rats' brain. Electrospinning and lithographic technique were used for developing nanofibrous-polylactic acid (PLA) and polyurethane (PU) based-scaffolds and micro-fluidic channels on Si-Chips respectively. Immunocytochemical and morphological analysis showed better cell-matrix interaction with profound adhesion, proliferation and migration on the developed scaffolds. Cell culture assay with microfluidic channel revealed the ability of developed channel system in guiding neuronal stem cell growth towards specified directions. These studies extend the possibility of using developed nanofibrous scaffolds and micro-fluidic channel system for future electrical signal transmission based on living neural stem cells.
Author
Johan Liu
Chalmers, Applied Physics, Electronics Material and Systems
Hans-Georg Kuhn
University of Gothenburg
Jing Yujia
Chalmers
East China University of Science and Technology
Jan-Olof Dahlberg
Chalmers
Linnea Ericsson
Chalmers
Anna Nilsson
Chalmers
Lena Nyberg
Chalmers, Applied Physics, Electronics Material and Systems
Behroz Ohady
Chalmers
Johan Svensson
Chalmers
Björn Carlberg
Chalmers, Applied Physics, Electronics Material and Systems
Christiana M. Cooper-Kuhn
University of Gothenburg
Teng Wang
Chalmers, Applied Physics, Electronics Material and Systems
Yihua Zhu
East China University of Science and Technology
Proceedings of the 2009 Electronic Components and Technology Conference
0569-5503 (ISSN)
1080-10859781424444762 (ISBN)
Subject Categories
Dentistry
DOI
10.1109/ECTC.2009.5074146
ISBN
9781424444762