Stem Cell Growth and Migration on Nanofibrous Polymer Scaffolds and Micro-Fluidic Channels on Silicon-Chip
Paper i proceeding, 2009

Stem cell growth and migration on nanofibrous scaffolds and micro-fluidic channels on Silicon-Chip were studied by using neural stem cells isolated from adult rats' brain. Electrospinning and lithographic technique were used for developing nanofibrous-polylactic acid (PLA) and polyurethane (PU) based-scaffolds and micro-fluidic channels on Si-Chips respectively. Immunocytochemical and morphological analysis showed better cell-matrix interaction with profound adhesion, proliferation and migration on the developed scaffolds. Cell culture assay with microfluidic channel revealed the ability of developed channel system in guiding neuronal stem cell growth towards specified directions. These studies extend the possibility of using developed nanofibrous scaffolds and micro-fluidic channel system for future electrical signal transmission based on living neural stem cells.

Författare

Johan Liu

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Hans-Georg Kuhn

Institute of Neuroscience and Physiology Gothenburg University

Jing Yujia

Chalmers University of Technology

East China University of Science and Technology

Jan-Olof Dahlberg

Chalmers University of Technology

Linnea Ericsson

Chalmers University of Technology

Anna Nilsson

Chalmers University of Technology

Lena Nyberg

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Behroz Ohady

Chalmers University of Technology

Johan Svensson

Chalmers University of Technology

Björn Carlberg

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Christiana M. Cooper-Kuhn

Institute of Neuroscience and Physiology Gothenburg University

Teng Wang

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Yihua Zhu

East China University of Science and Technology

Proceedings of the 2009 Electronic Components and Technology Conference

0569-5503 (ISSN)

1080-1085

Ämneskategorier

Odontologi

DOI

10.1109/ECTC.2009.5074146

ISBN

9781424444762