Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease
Journal article, 2019

Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.

metabolomics

gut microbiota

cardiometabolic diseases

metabotyping

targeted nutrition

personalized nutrition

precision nutrition

Author

Marie Palmnäs

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Carl Brunius

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Lin Shi

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Agnetha Rostgaard-Hansen

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Núria Estanyol Torres

University of Barcelona

Raúl González-Domínguez

University of Barcelona

Raúl Zamora-Ros

University of Barcelona

Ling Qun Ye

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jytte Halkjær

Danish Cancer Research Society Center

Anne Tjønneland

Danish Cancer Research Society Center

Gabriele Riccardi

University of Naples Federico II

Rosalba Giacco

University of Naples Federico II

Giuseppina Costabile

University of Naples Federico II

Claudia Vetrani

University of Naples Federico II

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Cristina Andres-Lacueva

University of Barcelona

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Advances in nutrition (Bethesda, Md.)

2156-5376 (ISSN)

DiGuMet Project: Diet x gut microbiome-based metabotypes to determine cardio-metabolic risk and tailor intervention strategies for improved health

Formas, 2018-01-01 -- 2021-12-31.

Subject Categories

Biological Sciences

Health Sciences

Nutrition and Dietetics

DOI

10.1093/advances/nmz121

More information

Created

1/7/2020 7