Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of type 2 diabetes in older Swedish women
Artikel i vetenskaplig tidskrift, 2017

Background: Diet is frequently associated with both the development and prevention of type 2 diabetes (T2D), but there is a lack of objective tools for assessing the relation between diet and T2D. Biomarkers of dietary intake are unconfounded by recall and reporting bias, and using multiple dietary biomarkers could help strengthen the link between a healthy diet and the prevention of T2D.Objective: The objective of this study was to explore how diet is related to glucose tolerance status (GTS) and to future development of T2D irrespective of common T2D and cardiovascular disease risk factors by using multiple dietary biomarkers.Design: Dietary biomarkers were measured in plasma from 64-y-old Swedish women with different GTS [normal glucose tolerance (NGT; n = 190), impaired glucose tolerance (IGT; n = 209), and diabetes (n = 230)]. The same subjects were followed up after 5 y to determine changes in glucose tolerance (n = 167 for NGT, n = 174 for IGT, and n = 159 for diabetes). ANCOVA and logistic regression were used to explore baseline data for associations between dietary biomarkers, GTS, and new T2D cases at follow-up (n = 69).Results: Of the 10 dietary biomarkers analyzed, β-alanine (beef) (P-raw < 0.001), alkylresorcinols C17 and C19 (whole-grain wheat and rye) (P-raw = 0.003 and 0.011), eicosapentaenoic acid (fish) (P-raw = 0.041), 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) (fish) (P-raw = 0.002), linoleic acid (P-raw < 0.001), oleic acid (P-raw = 0.003), and α-tocopherol (margarine and vegetable oil) (P-raw < 0.001) were associated with GTS, and CMPF (fish) (OR: 0.72; 95% CI: 0.56, 0.93; P-raw = 0.013) and α-tocopherol (OR: 0.71; 95% CI: 0.51, 0.98; P-raw = 0.041) were inversely associated with future T2D development.Conclusions: Several circulating dietary biomarkers were strongly associated with GTS after correction for known T2D risk factors, underlining the role of diet in the development and prevention of T2D. To our knowledge, this study is the first to use multiple dietary biomarkers to investigate the link between diet and disease risk.

metabolomics

biomarkers

diet

metabolome

prediabetes

nutrition

Författare

Otto Savolainen

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Mads Vendelbo Lind

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Göran Bergström

Göteborgs universitet

Björn Fagerberg

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

American Journal of Clinical Nutrition

0002-9165 (ISSN)

Vol. 106 5 1302-1310

Ämneskategorier

Endokrinologi och diabetes

Annan klinisk medicin

Näringslära

Infrastruktur

Chalmers infrastruktur för masspektrometri

Fundament

Grundläggande vetenskaper

Styrkeområden

Livsvetenskaper och teknik

DOI

10.3945/ajcn.117.152850

PubMed

28903960

Mer information

Senast uppdaterat

2018-06-18