Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden
Artikel i vetenskaplig tidskrift, 2018

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. INTRODUCTION: Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures-diet, microbes and environmental toxicants-during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: infant growth, obesity, neurological development and oral health.METHODS AND ANALYSIS: The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health.ETHICS AND DISSEMINATION: The NICE cohort has been approved by the Regional Ethical Review Board in Umeå, Sweden (2013/18-31M). Results will be disseminated through peer-reviewed journals and communicated on scientific conferences.

microbiology

allergy

immunology

nutrition

birth cohort

toxicants

Författare

Malin Barman

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Sahlgrenska akademin

Fiona Murray

Sunderby Research Unit

Angelina I. Bernardi

Göteborgs universitet

Karin Broberg

Karolinska Institutet

Sven Bölte

Stockholms läns landsting

Bill Hesselmar

Sahlgrenska akademin

Bo Jacobsson

Sahlgrenska akademin

Karin Jonsson

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Maria Kippler

Karolinska Institutet

Hardis Rabe

Göteborgs universitet

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

F. Sjoberg

Göteborgs universitet

Nicklas Strömberg

Umeå universitet

Marie Vahter

Karolinska Institutet

A. E. Wold

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Anna Sandin

Umeå universitet

Sunderby Research Unit

BMJ Open

2044-6055 (ISSN)

Vol. 8 10 e022013

Ämneskategorier

Pediatrik

Miljömedicin och yrkesmedicin

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

DOI

10.1136/bmjopen-2018-022013

PubMed

30344169

Mer information

Senast uppdaterat

2018-10-31