Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
Artikel i vetenskaplig tidskrift, 2020

Children growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected from 28 farming and 37 control children over the first 3 years of life using gas chromatography. Data on diet and other host factors were recorded and allergy was diagnosed at 8 years of age. Among all children, median propionic and butyric acid concentration increased over the first 3 years, and longer SCFAs typically appeared by 1 year of age. Farm children had higher levels of iso-butyric, iso-valeric and valeric acid at 3 years of age than rural controls. In addition, children with elder siblings had higher levels of valeric acid at 3 years of age, and dietary factors also affected SCFA pattern. High levels of valeric acid at 3 years of age were associated with low rate of eczema at 8 years of age. The fecal SCFA pattern in farm children suggests a more rapid maturation of the gut microbiota. Valeric acid or associated microbes may have protective potential against eczema.

Författare

Monica Gio-Batta

Göteborgs universitet

F. Sjoberg

Göteborgs universitet

Karin Jonsson

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Malin Barman

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Karolinska Institutet

Anna Carin Lundell

Göteborgs universitet

Ingegerd Adlerberth

Göteborgs universitet

Bill Hesselmar

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

A. E. Wold

Göteborgs universitet

Scientific Reports

2045-2322 (ISSN)

Vol. 10 1 22449

Nutrition i tidig ålder och immunologisk mognad med fokus på förebyggande av allergi

Vetenskapsrådet (VR), 2014-01-01 -- 2018-12-31.

Ämneskategorier

Pediatrik

Miljömedicin och yrkesmedicin

Näringslära

DOI

10.1038/s41598-020-79737-6

Mer information

Senast uppdaterat

2021-01-08