An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Artikel i vetenskaplig tidskrift, 2022
Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.
Författare
Elise Nordin
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Stine K. Steffensen
Aarhus Universitet
Bente B. Laursen
Aarhus Universitet
Sven Olof Andersson
Örebro universitet
Jan Erik Johansson
Örebro universitet
Per Åman
Sveriges lantbruksuniversitet (SLU)
Göran Hallmans
Umeå universitet
Michael Borre
Arhus Universitetshospital
Dan Stærk
Köpenhamns universitet
Kati Hanhineva
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Itä-Suomen Yliopisto
Inge S. Fomsgaard
Aarhus Universitet
Rikard Landberg
Umeå universitet
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Scientific Reports
2045-2322 (ISSN) 20452322 (eISSN)
Vol. 12 1 5260Ämneskategorier
Urologi och njurmedicin
Läkemedelskemi
Näringslära
DOI
10.1038/s41598-022-08856-z
PubMed
35347164