Ann-Sofie Cans
At Chalmers I am now pioneering a research program with a focus on nanosensor engineering and artificial cell structures to study the chemistry and biophysics of cells, and neuronal communication. Currently running projects involve development and application of artificial cell models to study
1) quantitative amperometric measurements on the effects of lipids composition in membrane dynamics and sorting inhigh curvature regions of nanotube biomembranes,
2) DNA-zipper-catalyzed artificial exocytosis, and
3) development of millisecond time resolved ultra-small biosensors constructed from enzyme nanoparticle bioconjugates for selective probing of molecules in vivo in the brain.
Showing 45 publications
Quantitative Analysis of Single Glutamatergic Vesicles in the Brain
Artificial Cells for Dissecting Exocytosis
Electrochemistry of Single-Vesicle Events
Generation of interconnected vesicles in a liposomal cell model
Counting the Number of Glutamate Molecules in Single Synaptic Vesicles
Ultrafast Glutamate Biosensor Recordings in Brain Slices Reveal Complex Single Exocytosis Transients
Counting the number of enzymes immobilized onto a nanoparticle-coated electrode
Monitoring the effect of osmotic stress on secretory vesicles and exocytosis
Co-detection of dopamine and glucose with high temporal resolution
Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release
Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
Development of Ultra-Fast Nanostructured Glucose Biosensor - Stoichiometry and Activity
Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis
The evidence for open and closed exocytosis as the primary release mechanism
The Effect of Excited Fluorophore on Vesicle Fusion at the Surface of the Electrode
Millisecond Time Resolved Electrochemical Detection of Non-Electroactive Neurotransmitter Release
Amperometric Detection of Single Vesicle Acetylcholine Release Events from an Artificial Cell
Two modes of exocytosis in an artificial cell
Using a Cell Model to Study the Effect of Cholesterol on Exocytosis
Composition Based Strategies for Controlling Radii in Lipid Nanotubes
The Role of Dense Core Nanoparticles in Regulation of Neuronal Communication
Electrochemcial Detection of Acetylcholine using Enzyme Functionalized Nanoparticles
A Secretory Artificial Cell for Exocytosis
Analytical tools to monitor exocytosis: A focus on new fluorescent probes and methods
Highlights of selected recent electrochemical measurements in living systems
A functioning artificial secretory cell
Highlights of 20 years of electrochemical measurements of exocytosis at cells and artificial cells
Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube
Electrochemical Probes for Spatial Detection of Exocytosis and Vesicles
Analytical approaches to investigate transmitter content and release from single secretory vesicles
Tools to monitor exocytosis: a focus on new fluorescent probes and methods
Budding and asymmetric protein microcompartmentation in giant vesicles containing two aqueous phases
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