Istvan Horvath

Researcher at Chemical Biology

Istvan Horvath is a researcher in Pernilla's lab.
The main focus of my research is protein misfolding and aggregation and its implications in various diseases including Parkinson’s disease Alzheimer’s disease and type 2 diabetes. My results contribute to the basic understanding of these protein misfolding diseases which will help to develop better treatment and prevention strategies.

Source: chalmers.se
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Showing 18 publications

2021

Macromolecular crowding modulates α-synuclein amyloid fiber growth

Istvan Horvath, Ranjeet Kumar, Pernilla Wittung Stafshede
Biophysical Journal. Vol. 120 (16), p. 3374-3381
Journal article
2021

Response to crowded conditions reveals compact nucleus for amyloid formation of folded protein

Tony Werner, Istvan Horvath, Pernilla Wittung Stafshede
QRB Discovery. Vol. 2
Journal article
2021

Effects of the toxic metals arsenite and cadmium on α-synuclein aggregation in vitro and in cells

Emma Lorentzon, Istvan Horvath, Ranjeet Kumar et al
International Journal of Molecular Sciences. Vol. 22 (21)
Journal article
2020

Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants

Emma Lorentzon, Ranjeet Kumar, Istvan Horvath et al
Biometals. Vol. 33 (2-3), p. 97-106
Journal article
2020

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Timothy R. Sampson, Collin Challis, Neha Jain et al
eLife. Vol. 9
Journal article
2020

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro

Nima Sasanian, David Bernson, Istvan Horvath et al
Biomolecules. Vol. 10 (6), p. 1-19
Journal article
2020

Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease

Tony Werner, Istvan Horvath, Pernilla Wittung Stafshede
Journal of Parkinsons Disease. Vol. 10 (3), p. 819-830
Review article
2020

Biochemical evidence of both copper chelation and oxygenase activity at the histidine brace

Søren Brander, Istvan Horvath, Johan Ipsen et al
Scientific Reports. Vol. 10 (1)
Journal article
2019

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

Sandra Rocha, Ranjeet Kumar, Istvan Horvath et al
Protein engineering, design & selection : PEDS. Vol. 32 (2), p. 59-66
Journal article
2019

Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells

Istvan Horvath, Stephanie Blockhuys, Darius Šulskis et al
ACS Chemical Neuroscience. Vol. 10 (11), p. 4659-4668
Journal article
2018

Abundant fish protein inhibits α-synuclein amyloid formation

Tony Werner, Ranjeet Kumar, Istvan Horvath et al
Scientific Reports. Vol. 8 (1)
Journal article
2018

Copper chaperone blocks amyloid formation via ternary complex

Istvan Horvath, Tony Werner, Ranjeet Kumar et al
Quarterly Reviews of Biophysics. Vol. 51
Journal article
2018

The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Vol. 118 (8), p. 75-81
Journal article
2018

In vitro analysis of α-synuclein amyloid formation and cross-reactivity

Istvan Horvath, Sandra Rocha, Pernilla Wittung Stafshede
Methods in Molecular Biology, p. 73-83
Book chapter
2017

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

Diana Ribeiro, Istvan Horvath, N. Heath et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 114 (42), p. 11127-11132
Journal article
2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Journal article
2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

Istvan Horvath, Pernilla Wittung Stafshede
Proceedings of the National Academy of Sciences of the United States of America. Vol. 113 (44), p. 12473-12477
Journal article
2015

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Martin Nors Perdersen, Vito Foderà, Istvan Horvath et al
Scientific Reports. Vol. 5, p. 10422-
Journal article

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