Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice
Artikel i vetenskaplig tidskrift, 2012

Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P=0.007), and reduced epididymal adipocyte size (P=0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and very-low-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P=0.0012 and 0.004, VLDL-cholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice. In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.

lipoprotein particle cholesterol profile


low-density lipoprotein receptor-deficient

en face histology


Britt Gabrielsson

Chalmers, Kemi- och bioteknik, Livsvetenskaper

Johannes Wikström

AstraZeneca AB

Robert Jakubowicz

Göteborgs universitet

Sofia Marmon

Chalmers, Kemi- och bioteknik, Livsvetenskaper

Nils-Gunnar Carlsson

Chalmers, Kemi- och bioteknik, Livsvetenskaper

Nina Jansson

Göteborgs universitet

Li-Ming Gan

AstraZeneca AB

Ingrid Undeland

Chalmers, Kemi- och bioteknik, Livsvetenskaper

Malin Lönn

Göteborgs universitet

Agneta Holmäng

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Kemi- och bioteknik, Livsvetenskaper

International Journal of Molecular Medicine

1107-3756 (ISSN)

Vol. 29 3 331-37


Endokrinologi och diabetes




Livsvetenskaper och teknik (2010-2018)





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