Exposure to a Farm Environment During Pregnancy Increases the Proportion of Arachidonic Acid in the Cord Sera of Offspring
Artikel i vetenskaplig tidskrift, 2019

Growing up in a farm environment is protective against allergy development. Various explanations have been put forward to explain this association. Fatty acids are regulators of immune function and the composition of fatty acids in the circulation system may affect immune development. Here, we investigate whether the fatty acid composition of cord serum differs for infants born to Farm (n = 26) or non-Farm mothers (n =29) in the FARMFLORA birth-cohort. For comparison, the levels of fatty acids in the maternal diet, serum and breast milk around 1 month post-partum were recorded. The fatty acids in the cord sera from infants born to Farm mothers had higher proportions of arachidonic acid (20:4 n-6) and adrenic acid (22:4 n-6) than those from infants born to non-Farm mothers. No differences were found for either arachidonic acid or adrenic acid in the diet, samples of the serum, or breast milk from Farm and non-Farm mothers obtained around 1 month post-partum. The arachidonic and adrenic acid levels in the cord blood were unrelated to allergy outcome for the infants. The results suggest that a farm environment may be associated with the fatty acid composition to which the fetus is exposed during pregnancy.

farming

arachidonic acid

adrenic acid

cord blood

fatty acids

Författare

Malin Barman

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Karin Jonsson

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Agnes E Wold

Sahlgrenska akademin

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Nutrients

2072-6643 (ISSN)

Vol. 11 238-

Nutrition i tidig ålder och immunologisk mognad med fokus på förebyggande av allergi

Vetenskapsrådet (VR), 2014-01-01 -- 2018-12-31.

Ämneskategorier

Annan medicin och hälsovetenskap

DOI

10.3390/nu11020238

PubMed

30678238

Mer information

Senast uppdaterat

2019-02-13