Proportions of polyunsaturated fatty acids in umbilical cord blood at birth are related to atopic eczema development in the first year of life
Artikel i vetenskaplig tidskrift, 2021

Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.

NICE birth cohort

Fatty acids



Atopic eczema

Arachidonic acid

Cord blood





Malin Barman

Karolinska Institutet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Mia Stråvik

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Karin Broberg

Lunds universitet

Karolinska Institutet

Anna Sandin

Umeå universitet

A. E. Wold

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap


2072-6643 (ISSN)

Vol. 13 11 3779

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