Identification of metabotypes in complex biological data using tensor decomposition
Artikel i vetenskaplig tidskrift, 2023

Differences in the physiological response to treatment, such as dietary intervention, has led to the development of precision approaches in nutrition and medicine to tailor treatment for improved benefits to the individual. One such approach is to identify metabotypes, i.e., groups of individuals with similar metabolic profiles and/or regulation. Metabotyping has previously been performed using e.g., principal component analysis (PCA) on matrix data. However, metabotyping methods suitable for more complex experimental designs such as repeated measures or cross-over studies are needed. We have developed a metabotyping method for tensor data, based on CANDECOMP/PARAFAC (CP) tensor decomposition. Metabotypes are inferred from CP scores using k-means clustering, and robustness is evaluated using bootstrapping of metabolites. As a proof-of-concept, we identified metabotypes from metabolomics data where 79 metabolites were analyzed in 8 time points postprandially in 17 overweight men that underwent a three-arm dietary crossover intervention. Two metabotypes were found, characterized by differences in amino acid metabolite concentration, that were differentially associated with baseline plasma creatinine (p = 0.007) and with the baseline metabolome (p = 0.004). These results suggest that CP decomposition provides a viable approach for metabotype identification directly from complex, high-dimensional data with improved biological interpretation compared to the more simplistic PCA approach. A simulation study together with results from measured data concluded that several preprocessing methods should be taken into consideration for CP-based metabotyping on complex tensor data.

Metabotyping

Data mining

Multiway analysis

Personalized nutrition

Tensor decomposition

Författare

Viktor Skantze

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

Chalmers, Life sciences, Livsmedelsvetenskap

Mikael Wallman

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

Ann-Sofie Sandberg

Chalmers, Life sciences, Livsmedelsvetenskap

Rikard Landberg

Chalmers, Life sciences, Livsmedelsvetenskap

Mats Jirstrand

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

Carl Brunius

Chalmers, Life sciences, Livsmedelsvetenskap

Chemometrics and Intelligent Laboratory Systems

0169-7439 (ISSN) 18733239 (eISSN)

Vol. 233 104733

Optimal kost utifrån metabotyp för hälsa och vällevnad

Formas (2016-00314), 2016-01-01 -- 2021-12-31.

Ämneskategorier

Farmaceutisk vetenskap

Bioinformatik och systembiologi

Näringslära

DOI

10.1016/j.chemolab.2022.104733

Mer information

Senast uppdaterat

2023-01-13