Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.
Journal article, 2016

SCOPE: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome? METHOD AND RESULTS: A randomised crossover trial with 15 healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics. The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and arginine metabolism were affected by the intervention. The effect on arginine metabolism was supported by an increase in blood nitric oxide in males on the herring diet. CONCLUSION: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.

Author

ANDREW VINCENT

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Otto Savolainen

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Partho Sen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Nils-Gunnar Carlsson

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Annette Almgren

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Helen Lindqvist

University of Gothenburg

Mads Vendelbo Lind

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Ingrid Undeland

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Alastair Ross

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Molecular nutrition & food research

1613-4133 (eISSN)

Vol. 61 3 Art no UNSP 1600400-

Subject Categories

Analytical Chemistry

Food Science

Nutrition and Dietetics

Infrastructure

Chalmers Infrastructure for Mass spectrometry

Roots

Basic sciences

Areas of Advance

Life Science Engineering

DOI

10.1002/mnfr.201600400

PubMed

27801550

More information

Created

10/7/2017