Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
Artikel i vetenskaplig tidskrift, 2021

Allergic diseases are the most common chronic diseases in childrenin the Western world, but little is know about what factors influence immune maturation and allergy development. We therefore aimed to associate infant and maternal metabolomes to T- and B-cell subpopulations and allergy diagnosis. We performed liquid chromatography-mass spectrometry based untargeted metabolomics on blood plasma from mothers (third trimester, n = 605; delivery, n = 558) and from the umbilical cord (n = 366). The measured metabolomes were associated to T- and B-cell subpopulations up to 4 months after delivery and to doctor´s diagnosed eczema, food allergy and asthma at one year of age using random forest analysis. Maternal and cord plasma at delivery could predict the number of CD24+CD38low memory B-cells (p = 0.033, n = 26 and p = 0.009, n = 22), but future allergy status could not be distinguished from any of the three measured metabolomes. Replication of previous literature findings showed hypoxanthine to be upregulated in the umbilical cord of children with subsequent asthma. This exploratory study suggests foetal immune programming occuring during pregnancy as the metabolomic profiles of mothers and infants at delivery related to infants’ B-cell maturation.

Författare

Olle Hartvigsson

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Malin Barman

Karolinska Institutet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Hardis Rabe

Göteborgs universitet

Anna Sandin

Umeå universitet

A. E. Wold

Göteborgs universitet

Carl Brunius

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Scientific Reports

2045-2322 (ISSN)

Vol. 11 1 12706

Nutrition i tidig ålder och immunologisk mognad med fokus på förebyggande av allergi

Vetenskapsrådet (VR) (2013-3154), 2014-01-01 -- 2018-12-31.

Ett systemtoxikologibaserat angreppssätt för bedömning av kombinationseffekter av toxiska metaller tidigt i livet

Formas (2018-02275), 2018-12-01 -- 2022-11-30.

Ämneskategorier

Pediatrik

Immunologi

Lungmedicin och allergi

DOI

10.1038/s41598-021-92239-3

PubMed

34135462

Mer information

Senast uppdaterat

2021-06-30