Sriram Kesarimangalam

Researcher at Chemical Biology

I have a PhD in Nanoscience and technology and I am currently working as a specialist researcher in Fredrik Westerlund's group. My expertise is in design and fabrication of micro- nanofluidic devices for single molecule biophysics applications. In addition, I work on projects involving "optical DNA mapping" to study plasmid mediated antibiotic resistance, DNA-protein interactions etc.

Source: chalmers.se
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Showing 43 publications

2024
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Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex

Carl Ivar Möller, Rajhans Sharma, Robin Öz et al
Biochemical and Biophysical Research Communications. Vol. 695
Journal article
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2024
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Fluorescence Microscopy of Nanochannel-Confined DNA

Sriram Kesarimangalam, Fredrik Persson, Joachim Fritzsche et al
Methods in Molecular Biology, p. 175-202
Book chapter
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2023
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Identification and characterization of plasmids carrying the mobile colistin resistance gene mcr-1 using optical DNA mapping

Sriram Kesarimangalam, Moa Wranne, Tsegaye Sewunet et al
JAC-Antimicrobial Resistance. Vol. 5 (1)
Journal article
2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Sriram Kesarimangalam, Marziyeh Ghaeidamini et al
European Biophysics Journal. Vol. 52 (SUPPL 1), p. S205-S205
Other conference contribution
2023

Plasmonic polymer nanoantenna arrays for electrically tunable and electrode-free metasurfaces

Seunghyun Lee, Daseul Jeong, Sriram Kesarimangalam et al
Journal of Materials Chemistry A. Vol. 11 (40), p. 21569-21576
Journal article
2023

Single molecule experiments highlight the role of NBS1 and Xrs2 in DNA tethering by MRN and MRX

Carl Ivar Möller, Giordano Reginato, Elda Cannavo et al
European Biophysics Journal. Vol. 52 (1 (suppl.)), p. S197-S197
Other text in scientific journal
2023
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Strain-level bacterial typing directly from patient samples using optical DNA mapping

My Nyblom, Anna Johnning, Karolin Frykholm et al
COMMUNICATIONS MEDICINE. Vol. 3 (31)
Journal article
2023

A single-molecule view on non-homologous end-joining in bacteria

Fredrik Westerlund, Evgeniya Pavlova, Anusha Budida et al
European Biophysics Journal. Vol. 52 (SUPPL 1), p. S213-S213
Other conference contribution
2023
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Polymer Brushes on Silica Nanostructures Prepared by Aminopropylsilatrane Click Chemistry: Superior Antifouling and Biofunctionality

John Andersson, Julia Järlebark, Sriram Kesarimangalam et al
ACS Applied Materials & Interfaces. Vol. 15 (7), p. 10228-10239
Journal article
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2023
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Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Rajhans Sharma, Quentin Lubart et al
Nanoscale. Vol. 15 (46), p. 18737-18744
Journal article
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2022
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High diversity of blaNDM-1-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital

Sriram Kesarimangalam, Elina Ekedahl, Ngoc Thi Bich Hoang et al
International Journal of Antimicrobial Agents. Vol. 59 (2)
Journal article
2022
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Nanofluidic Trapping of Faceted Colloidal Nanocrystals for Parallel Single-Particle Catalysis

Sune Levin, Sarah Lerch, Astrid Boje et al
ACS Nano. Vol. 16 (9), p. 15206-15214
Journal article
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2022
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Organic Anisotropic Excitonic Optical Nanoantennas

Evan S.H. Kang, Sriram Kesarimangalam, Inho Jeon et al
Advanced Science. Vol. 9 (23)
Journal article
2022
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DNA in Nanochannels - Theory and Applications

Karolin Frykholm, Vilhelm Müller, Sriram Kesarimangalam et al
Quarterly Reviews of Biophysics. Vol. 55
Review article
2022
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Fecal carriage and clonal dissemination of blaNDM-1 carrying Klebsiella pneumoniae sequence type 147 at an intensive care unit in Lao PDR

Tsegaye Sewunet, Sriram Kesarimangalam, Ha Hoang Nguyen et al
PLoS ONE. Vol. 17 (10)
Journal article
2021
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Optical dna mapping of plasmids reveals clonal spread of carbapenem-resistant klebsiella pneumoniae in a large thai hospital

Sriram Kesarimangalam, Tsegaye Sewunet, Walaiporn Wangchinda et al
Antibiotics. Vol. 10 (9)
Journal article
2021

Single Molecule Experiments Define the Role of Nbs1 and Xrs2 in DNA Tethering by MRN and MRX in DSB Repair

Carl Ivar Möller, Rajhans Sharma, Robin Öz et al
Other conference contribution
2021
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The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al
Nucleic Acids Research. Vol. 49 (8), p. 4550-4563
Journal article
2021
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Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

Robin Öz, Jing L. Wang, Raphael Guerois et al
Nucleic Acids Research. Vol. 49 (5), p. 2629-2641
Journal article
2021
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Identity of blactx-m carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections

N. Karami, Sriram Kesarimangalam, Shora Yazdanshenas et al
Microorganisms. Vol. 9 (6)
Journal article
2021
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A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids

Sriram Kesarimangalam, Yii Lih Lin, Tsegaye Sewunet et al
Micromachines. Vol. 12 (10)
Journal article
2020
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Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

Rajhans Sharma, Sriram Kesarimangalam, Erik D. Holmstrom et al
Biochemical and Biophysical Research Communications. Vol. 533 (1), p. 175-180
Journal article
2020

Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

Rajhans Sharma, Sriram Kesarimangalam, Erik D. Holmstrom et al
Biophysical Journal. Vol. 118 (3)
Paper in proceeding
2020

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

Quentin Lubart, Sune Levin, Stephan Block et al
Other conference contribution
2020
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Cultivation-Free Typing of Bacteria Using Optical DNA Mapping

Vilhelm Müller, My Nyblom, Anna Johnning et al
ACS Infectious Diseases. Vol. 6 (5), p. 1076-1084
Journal article
2020
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Optical maps of plasmids as a proxy for clonal spread of MDR bacteria: A case study of an outbreak in a rural Ethiopian hospital

Yii Lih Lin, Tsegaye Sewunet, Sriram Kesarimangalam et al
Journal of Antimicrobial Chemotherapy. Vol. 75 (10), p. 2804-2811
Journal article
2020

Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

Robin Öz, Rajhans Sharma, Sriram Kesarimangalam et al
Other conference contribution
2020

DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund
Other conference contribution
2020
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Phosphorylated CtIP bridges DNA to promote annealing of broken ends

Robin Öz, Sean Howard, Rajhans Sharma et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (35), p. 21403-21412
Journal article
2019

Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples

Sriram Kesarimangalam, Yii Lih Lin, Tsegaye Sewunet et al
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 856-857
Paper in proceeding
2019

High throughput size-determination and multiplexed fluorescence analysis of single biological particles in a nanofluidic device

Quentin Lubart, Sune Levin, Stephan Block et al
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 1420-1421
Paper in proceeding
2019

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Kai Jiang, Sandra Rocha, Alvina Westling et al
Biophysical Journal
Paper in proceeding
2019

Optical DNA mapping using nanochannels for identification of plasmids carrying carbapenemase blandm-1 gene from patients admitted to a Vietnamese hospital

Sriram Kesarimangalam, Maud Nilsson, Björn Berglund et al
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 805-806
Paper in proceeding
2019
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Enzyme-free optical DNA mapping of the human genome using competitive binding

Vilhelm Müller, Albertas Dvirnas, John Andersson et al
Nucleic Acids Research. Vol. 47 (15)
Journal article
2019
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A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund
Nanoscale. Vol. 11 (4), p. 2071-2078
Journal article
2019
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Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al
Quarterly Reviews of Biophysics. Vol. 52, p. e2-e2
Journal article
2019

Bacterial identification by optical mapping of genomic DNA in nanofluidic channels

My Nyblom, Vilhelm Müller, Anna Johnning et al
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 821-822
Paper in proceeding
2019

Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

Anna Lindblom, Sriram Kesarimangalam, Vilhelm Müller et al
Diagnostic Microbiology and Infectious Disease. Vol. 93 (4), p. 380-385
Journal article
2018
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Alpha-Synuclein Modulates the Physical Properties of DNA

Kai Jiang, Sandra Rocha, Alvina Westling et al
Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690
Journal article
2018

A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund
Biophysical Journal. Vol. 114 (3)
Journal article
2018

Interactions between DNA and HIV-1 Nucleocapsid Protein Studied using Nanofluidic Channels

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al
Paper in proceeding
2018

Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids

Yii Lih Lin, Tsegaye Sewunet, Sriram Kesarimangalam et al
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Vol. 3, p. 1822-1825
Paper in proceeding

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