Sriram Kesarimangalam

Researcher at Chemical Biology

I have a PhD in Nanoscience and technology and I am currently working as a specialist researcher in Fredrik Westerlund's group. My expertise is in design and fabrication of micro- nanofluidic devices for single molecule biophysics applications. In addition, I work on projects involving "optical DNA mapping" to study plasmid mediated antibiotic resistance, DNA-protein interactions etc.

Source: chalmers.se

Contact Details ORCID

Publications (45)
Projects (0)

Showing 45 publications

2024

Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex

Carl Ivar Möller, Rajhans Sharma, Robin Öz et al

Biochemical and Biophysical Research Communications. Vol. 695

Journal article

Show project

2024

Fluorescence Microscopy of Nanochannel-Confined DNA

Sriram Kesarimangalam, Fredrik Persson, Joachim Fritzsche et al

Methods in Molecular Biology. Vol. 2694, p. 175-202

Book chapter

Show project

2024

Nanofluidics highlights importance of CtIP's tetrameric structure for DNA repair

Carl Ivar Möller, Sriram Kesarimangalam, Ilaria Ceppi et al

Biophysical Journal. Vol. 123 (3), p. 148A-148A

Other conference contribution

2024

Comparison of CTX-M encoding plasmids present during the early phase of the ESBL pandemic in western Sweden

Moa Wranne, N. Karami, Sriram Kesarimangalam et al

Scientific Reports. Vol. 14 (1), p. 11880-

Journal article

Show project

2023

Identification and characterization of plasmids carrying the mobile colistin resistance gene mcr-1 using optical DNA mapping

Sriram Kesarimangalam, Moa Wranne, Tsegaye Sewunet et al

JAC-Antimicrobial Resistance. Vol. 5 (1)

Journal article

2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Sriram Kesarimangalam, Marziyeh Ghaeidamini et al

European Biophysics Journal. Vol. 52 (SUPPL 1), p. S205-S205

Other conference contribution

2023

Plasmonic polymer nanoantenna arrays for electrically tunable and electrode-free metasurfaces

Seunghyun Lee, Daseul Jeong, Sriram Kesarimangalam et al

Journal of Materials Chemistry A. Vol. 11 (40), p. 21569-21576

Journal article

2023

Single molecule experiments highlight the role of NBS1 and Xrs2 in DNA tethering by MRN and MRX

Carl Ivar Möller, Giordano Reginato, Elda Cannavo et al

European Biophysics Journal. Vol. 52 (1 (suppl.)), p. S197-S197

Other text in scientific journal

2023

Strain-level bacterial typing directly from patient samples using optical DNA mapping

My Nyblom, Anna Johnning, Karolin Frykholm et al

Communications Medicine. Vol. 3 (31)

Journal article

2023

A single-molecule view on non-homologous end-joining in bacteria

Fredrik Westerlund, Evgeniya Pavlova, Anusha Budida et al

European Biophysics Journal. Vol. 52 (SUPPL 1), p. S213-S213

Other conference contribution

2023

Polymer Brushes on Silica Nanostructures Prepared by Aminopropylsilatrane Click Chemistry: Superior Antifouling and Biofunctionality

John Andersson, Julia Järlebark, Sriram Kesarimangalam et al

ACS Applied Materials & Interfaces. Vol. 15 (7), p. 10228-10239

Journal article

Show project

2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Rajhans Sharma, Quentin Lubart et al

Nanoscale. Vol. 15 (46), p. 18737-18744

Journal article

Show project

2022

High diversity of bla<inf>NDM-1</inf>-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital

Sriram Kesarimangalam, Elina Ekedahl, Ngoc Thi Bich Hoang et al

International Journal of Antimicrobial Agents. Vol. 59 (2)

Journal article

2022

Nanofluidic Trapping of Faceted Colloidal Nanocrystals for Parallel Single-Particle Catalysis

Sune Levin, Sarah Lerch, Astrid Boje et al

ACS Nano. Vol. 16 (9), p. 15206-15214

Journal article

Show project

2022

Organic Anisotropic Excitonic Optical Nanoantennas

Evan S.H. Kang, Sriram Kesarimangalam, Inho Jeon et al

Advanced Science. Vol. 9 (23)

Journal article

2022

DNA in Nanochannels - Theory and Applications

Karolin Frykholm, Vilhelm Müller, Sriram Kesarimangalam et al

Quarterly Reviews of Biophysics. Vol. 55

Review article

2022

Fecal carriage and clonal dissemination of blaNDM-1 carrying Klebsiella pneumoniae sequence type 147 at an intensive care unit in Lao PDR

Tsegaye Sewunet, Sriram Kesarimangalam, Ha Hoang Nguyen et al

PLoS ONE. Vol. 17 (10)

Journal article

2021

Optical dna mapping of plasmids reveals clonal spread of carbapenem-resistant klebsiella pneumoniae in a large thai hospital

Sriram Kesarimangalam, Tsegaye Sewunet, Walaiporn Wangchinda et al

Antibiotics. Vol. 10 (9)

Journal article

2021

Single Molecule Experiments Define the Role of Nbs1 and Xrs2 in DNA Tethering by MRN and MRX in DSB Repair

Carl Ivar Möller, Rajhans Sharma, Robin Öz et al

Other conference contribution

2021

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al

Nucleic Acids Research. Vol. 49 (8), p. 4550-4563

Journal article

2021

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

Robin Öz, Jing L. Wang, Raphael Guerois et al

Nucleic Acids Research. Vol. 49 (5), p. 2629-2641

Journal article

2021

Identity of bla<inf>ctx-m</inf> carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections

N. Karami, Sriram Kesarimangalam, Shora Yazdanshenas et al

Microorganisms. Vol. 9 (6)

Journal article

2021

A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids

Sriram Kesarimangalam, Yii Lih Lin, Tsegaye Sewunet et al

Micromachines. Vol. 12 (10)

Journal article

2020

Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

Rajhans Sharma, Sriram Kesarimangalam, Erik D. Holmstrom et al

Biochemical and Biophysical Research Communications. Vol. 533 (1), p. 175-180

Journal article

2020

Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

Rajhans Sharma, Sriram Kesarimangalam, Erik D. Holmstrom et al

Biophysical Journal. Vol. 118 (3)

Paper in proceeding

2020

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

Quentin Lubart, Sune Levin, Stephan Block et al

Other conference contribution

2020

Cultivation-Free Typing of Bacteria Using Optical DNA Mapping

Vilhelm Müller, My Nyblom, Anna Johnning et al

ACS Infectious Diseases. Vol. 6 (5), p. 1076-1084

Journal article

2020

Optical maps of plasmids as a proxy for clonal spread of MDR bacteria: A case study of an outbreak in a rural Ethiopian hospital

Yii Lih Lin, Tsegaye Sewunet, Sriram Kesarimangalam et al

Journal of Antimicrobial Chemotherapy. Vol. 75 (10), p. 2804-2811

Journal article

2020

Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

Robin Öz, Rajhans Sharma, Sriram Kesarimangalam et al

Other conference contribution

2020

DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund

Other conference contribution

2020

Phosphorylated CtIP bridges DNA to promote annealing of broken ends

Robin Öz, Sean Howard, Rajhans Sharma et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (35), p. 21403-21412

Journal article

2019

Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples

Sriram Kesarimangalam, Yii Lih Lin, Tsegaye Sewunet et al

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 856-857

Paper in proceeding

2019

High throughput size-determination and multiplexed fluorescence analysis of single biological particles in a nanofluidic device

Quentin Lubart, Sune Levin, Stephan Block et al

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 1420-1421

Paper in proceeding

2019

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Kai Jiang, Sandra Rocha, Alvina Westling et al

Biophysical Journal

Paper in proceeding

2019

Optical DNA mapping using nanochannels for identification of plasmids carrying carbapenemase blandm-1 gene from patients admitted to a Vietnamese hospital

Sriram Kesarimangalam, Maud Nilsson, Björn Berglund et al

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 805-806

Paper in proceeding

2019

Enzyme-free optical DNA mapping of the human genome using competitive binding

Vilhelm Müller, Albertas Dvirnas, John Andersson et al

Nucleic Acids Research. Vol. 47 (15)

Journal article

2019

A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund

Nanoscale. Vol. 11 (4), p. 2071-2078

Journal article

2019

Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al

Quarterly Reviews of Biophysics. Vol. 52, p. e2-e2

Journal article

2019

Bacterial identification by optical mapping of genomic DNA in nanofluidic channels

My Nyblom, Vilhelm Müller, Anna Johnning et al

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 821-822

Paper in proceeding

2019

Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Santosh Kumar Bikarolla, Viveka Nordberg, Fredrika Rajer et al

mBio. Vol. 10 (4)

Journal article

2019

Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

Anna Lindblom, Sriram Kesarimangalam, Vilhelm Müller et al

Diagnostic Microbiology and Infectious Disease. Vol. 93 (4), p. 380-385

Journal article

2018

Alpha-Synuclein Modulates the Physical Properties of DNA

Kai Jiang, Sandra Rocha, Alvina Westling et al

Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690

Journal article

2018

A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level

Robin Öz, Sriram Kesarimangalam, Fredrik Westerlund

Biophysical Journal. Vol. 114 (3)

Journal article

2018

Interactions between DNA and HIV-1 Nucleocapsid Protein Studied using Nanofluidic Channels

Kai Jiang, Nicolas Humbert, Sriram Kesarimangalam et al

Paper in proceeding

2018

Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids

Yii Lih Lin, Tsegaye Sewunet, Sriram Kesarimangalam et al

22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Vol. 3, p. 1822-1825

Paper in proceeding

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