Yun Chen
Yun Chen is a Senior Researcher at the Department of Life Sciences. His research is focused on accelerating the development of future cell factories through integrated approach combining synthetic biology, systems biology and evolution engineering. The aim is to develop novel, efficient microbial cell factories that can be used to slove a variety of societal challenges in environment, energy and health.
Showing 64 publications
Increased CO
Cinnamic acid and p-coumaric acid are metabolized to 4-hydroxybenzoic acid by Yarrowia lipolytica
Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
Optimizing yeast for high-level production of kaempferol and quercetin
Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae
Metabolic engineering: Tools and applications
Metabolic reconfiguration enables synthetic reductive metabolism in yeast
Editorial: Genomic strategies for efficient microbial cell factories
Strategies to increase tolerance and robustness of industrial microorganisms
Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis
Metabolic Engineering of Yeast
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics
De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
Strategies and challenges with the microbial conversion of methanol to high-value chemicals
Current state of aromatics production using yeast: achievements and challenges
Third-generation biorefineries as the means to produce fuels and chemicals from CO2
Harnessing xylose pathways for biofuels production
Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative
Modular Pathway Rewiring of Yeast for Amino Acid Production
Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains
Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C
Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae
Biobased organic acids production by metabolically engineered microorganisms
Microbial acetyl-CoA metabolism and metabolic engineering
De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae
Enabling Technologies to Advance Microbial Isoprenoid Production
Altered sterol composition renders yeast thermotolerant
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae
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Showing 10 research projects
Using metabolic modelling to identify new therapeutic targets for triple-negative breast cancer
Direct fermentation route for sustainable plastics and superabsorbent polymers
Increasing oxygen utilisation in biotechnological processes
Microbial synthesis of medicinal natural products
Production of Benzylisoquinoline Alkaloids in Yeast
Systems metabolic engineering of yeast for production of flavonoids
Biosynthesis of the high-value plant secondary metabolites in yeast
Engineering xylose metabolism for multiple products
Design and Assembly of Novel Pathways for Advanced Biofuel Synthesis