Yun Chen

Senior Researcher at Systems and Synthetic Biology

Yun Chen is a Senior Researcher at the Department of Life Sciences. His research is focused on accelerating the development of future cell factories through integrated approach combining synthetic biology, systems biology and evolution engineering. The aim is to develop novel, efficient microbial cell factories that can be used to slove a variety of societal challenges in environment, energy and health.

Source: chalmers.se

Contact Details ORCID

Publications (69)
Projects (10)

Showing 69 publications

2025

Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces cerevisiae

Xiaowei Li, Yanyan Wang, Xin Chen et al

Nature Communications. Vol. 16 (1)

Journal article

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2025

Metabolomics analysis of osmotic tolerance enhancement mechanism of wheat gluten peptides on industrial yeast

Xiaofan Jin, Mingwei Shao, Jun Ding et al

Food Chemistry. Vol. 482

Journal article

2024

Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms

Jiwei Mao, Hongyu Zhang, Yu Chen et al

Biotechnology Advances. Vol. 74

Review article

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2024

Increased CO<inf>2</inf> fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast

Ning Qin, Lingyun Li, Xiaozhen Wan et al

Nature Communications. Vol. 15 (1)

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2024

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Xiang Jiao, Xiaozhi Fu, Qishuang Li et al

Nature Communications. Vol. 15, p. 8759-

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2024

Phylogenetic analysis and functional characterization of norcoclaurine synthase involved in benzylisoquinoline alkaloids biosynthesis in Stephania tetrandra

Xinyi Li, Qishuang Li, Xiang Jiao et al

Journal of Cellular Physiology. Vol. 239 (10)

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2024

Characterization of CYP82 genes involved in the biosynthesis of structurally diverse benzylisoquinoline alkaloids in Corydalis yanhusuo

Xiuyu Liu, Ying Ma, Junling Bu et al

Plant Molecular Biology. Vol. 114 (2)

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2024

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

Qishuang Li, Xiang Jiao, Xinyi Li et al

Journal of Integrative Plant Biology. Vol. 66 (8), p. 1703-1717

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2023

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

Xiuyu Liu, Xiang Jiao, Yatian Cheng et al

Microbial Cell Factories. Vol. 22 (1)

Journal article

2023

Cinnamic acid and p-coumaric acid are metabolized to 4-hydroxybenzoic acid by Yarrowia lipolytica

Oliver Konzock, Marta Tous Mohedano, Irene Cibin et al

AMB Express. Vol. 13 (1)

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2023

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

Ning Qin, Lingyun Li, Xu Ji et al

Cell. Vol. 186 (4), p. 748-763.e15

Journal article

2023

Restricting Promiscuity of Plant Flavonoid 3'-Hydroxylase and 4'-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli

Juan Liu, Zhiqiang Xiao, Siqi Zhang et al

Journal of Agricultural and Food Chemistry. Vol. 71 (25), p. 9826-9835

Journal article

2023

Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast

Jiwei Mao, Marta Tous Mohedano, Jing Fu et al

Metabolic Engineering. Vol. 79, p. 192-202

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2023

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

Chunjun Zhan, Xiaowei Li, Guangxu Lan et al

Nature Catalysis. Vol. 6 (5), p. 435-450

Journal article

2023

Optimizing yeast for high-level production of kaempferol and quercetin

Musa Tartik, Juan Liu, Marta Tous Mohedano et al

Microbial Cell Factories. Vol. 22 (1)

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2023

Metabolic engineering: Tools and applications

Yun Chen, Jiazhang Lian, J. Hou

Engineering Microbiology. Vol. 3 (4)

Other text in scientific journal

2023

A highly efficient transcriptome-based biosynthesis of non-ethanol chemicals in Crabtree negative Saccharomyces cerevisiae

Zhen Yao, Yufeng Guo, Huan Wang et al

Biotechnology for Biofuels and Bioproducts. Vol. 16 (1)

Journal article

2023

Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae

Marta Tous Mohedano, Jiwei Mao, Yun Chen

ACS Synthetic Biology. Vol. 12 (1), p. 144-152

Journal article

2022

Metabolic reconfiguration enables synthetic reductive metabolism in yeast

Tao Yu, Quanli Liu, Xiang Wang et al

Nature Metabolism. Vol. 4 (11), p. 1551-1559

Journal article

2022

Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids

Junling Bu, Xiuhua Zhang, Qishuang Li et al

Horticulture Research. Vol. 9

Journal article

2022

Editorial: Genomic strategies for efficient microbial cell factories

Eugene Fletcher, Yun Chen, Luis Caspeta-Guadarrama et al

Frontiers in Bioengineering and Biotechnology. Vol. 10

Other text in scientific journal

2022

Strategies to increase tolerance and robustness of industrial microorganisms

Marta Tous Mohedano, Oliver Konzock, Yun Chen

Synthetic and Systems Biotechnology. Vol. 7 (1), p. 533-540

Journal article

2021

Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis

Xiaowei Li, Yanyan Wang, Gang Li et al

Nature Catalysis. Vol. 4 (9), p. 783-796

Journal article

2021

Functional characterization of (S)–N-methylcoclaurine 3′-hydroxylase (NMCH) involved in the biosynthesis of benzylisoquinoline alkaloids in Corydalis yanhusuo

Xiuyu Liu, Junling Bu, Ying Ma et al

Plant Physiology and Biochemistry. Vol. 168, p. 507-515

Journal article

2021

Metabolic Engineering of Yeast

Rui Pereira, Olena Ishchuk, Xiaowei Li et al

Metabolic Engineering: Concepts and Applications: Volume 13a and 13b. Vol. 13, p. 689-733

Book chapter

2021

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Quanli Liu, Yi Liu, Gang Li et al

Nature Communications. Vol. 12 (1)

Journal article

2021

Yeast optimizes metal utilization based on metabolic network and enzyme kinetics

Yu Chen, Feiran Li, Jiwei Mao et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 118 (12)

Journal article

2021

Strategies and challenges with the microbial conversion of methanol to high-value chemicals

Chunjun Zhan, Xiaowei Li, Yankun Yang et al

Biotechnology and Bioengineering. Vol. 118 (10), p. 3655-3668

Review article

2020

Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Zhu Zhiwei, Yating Hu, Paulo Teixeira et al

Nature Catalysis. Vol. 3 (1), p. 64-74

Journal article

2020

Current state of aromatics production using yeast: achievements and challenges

Quanli Liu, Yi Liu, Yun Chen et al

Current Opinion in Biotechnology. Vol. 65, p. 65-74

Review article

2020

Third-generation biorefineries as the means to produce fuels and chemicals from CO2

Zihe Liu, Kai Wang, Yun Chen et al

Nature Catalysis. Vol. 3 (3), p. 274-288

Review article

2020

Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution

Rui Pereira, Elsayed Mohamed, Mohammad Radi et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (45), p. 27954-27961

Journal article

2020

Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production

Ning Qin, Lingyun Li, Xu Ji et al

ACS Synthetic Biology. Vol. 9 (12), p. 3236-3244

Journal article

2019

Harnessing xylose pathways for biofuels production

Xiaowei Li, Yun Chen, Jens Christian Froslev Nielsen

Current Opinion in Biotechnology. Vol. 57, p. 56-65

Review article

2019

Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

Gheorghe M. Borja, A. Rodriguez, Kate Campbell et al

Microbial Cell Factories. Vol. 18 (1)

Journal article

2019

Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

Alexandra Linda Bergman, John Hellgren, Thomas Moritz et al

Microbial Cell Factories. Vol. 18 (1)

Journal article

2019

Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

Tian Ma, Bin Shi, Ziling Ye et al

Metabolic Engineering. Vol. 52, p. 134-142

Journal article

2019

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

Rui Pereira, Yongjun Wei, Elsayed Mohamed et al

Metabolic Engineering. Vol. 56, p. 130-141

Journal article

2019

Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome

Alexandra Linda Bergman, Dóra Vitay, John Hellgren et al

FEMS Yeast Research. Vol. 19 (3)

Journal article

2019

Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae

Yasaman Dabirian, Xiaowei Li, Yun Chen et al

ACS Synthetic Biology. Vol. 8 (9), p. 1968-1975

Journal article

2019

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Quanli Liu, Tao Yu, Xiaowei Li et al

Nature Communications. Vol. 10 (1)

Journal article

2018

Modular Pathway Rewiring of Yeast for Amino Acid Production

Quanli Liu, Tao Yu, Kate Campbell et al

Methods in Enzymology. Vol. 608, p. 417-439

Book chapter

2018

Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Zongijie Dai, Mingtao Huang, Yun Chen et al

Nature Communications. Vol. 9 (1)

Journal article

2017

Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains

A. Rodriguez, Yun Chen, Sakda Khoomrung et al

Metabolic Engineering. Vol. 44, p. 265-272

Journal article

2017

Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses

Guodong Liu, Yun Chen, N. J. Faergeman et al

FEMS Yeast Research. Vol. 17 (6)

Journal article

2017

Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae

Stefan Tippmann, Raphael Ferreira, Verena Siewers et al

Journal of Industrial Microbiology and Biotechnology. Vol. 44 (6), p. 911-922

Journal article

2016

Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C

Luis Caspeta-Guadarrama, Yun Chen, Jens B Nielsen

Scientific Reports. Vol. 6, p. Art. no. 27003-

Journal article

2016

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

K. R. Kildegaard, N. B. Jensen, K. Schneider et al

Microbial Cell Factories. Vol. 15 (1)

Journal article

2016

Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

Alexandra Linda Bergman, Verena Siewers, Jens B Nielsen et al

AMB Express. Vol. 6 (1)

Journal article

2016

Biobased organic acids production by metabolically engineered microorganisms

Yun Chen, Jens B Nielsen

Current Opinion in Biotechnology. Vol. 37, p. 165-172

Review article

2015

Microbial acetyl-CoA metabolism and metabolic engineering

Anastasia Krivoruchko, Yiming Zhang, Verena Siewers et al

Metabolic Engineering. Vol. 28, p. 28-42

Other text in scientific journal

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2015

Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase

Yun Chen, Yiming Zhang, Verena Siewers et al

FEMS Yeast Research. Vol. 15 (3), p. 1-8

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2015

Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Yiming Zhang, Guodong Liu, Martin Engqvist et al

Microbial Cell Factories. Vol. 14 (116)

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2015

Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

K. R. Kildegaard, Zheng Wang, Yun Chen et al

Metabolic Engineering Communications. Vol. 2, p. 132-136

Journal article

2015

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

M. Li, K. R. Kildegaard, Yun Chen et al

Metabolic Engineering. Vol. 32, p. 1-11

Journal article

2015

Functional pyruvate formate lyase pathway expressed with two different electron donors in Saccharomyces cerevisiae at aerobic growth

Yiming Zhang, Zongijie Dai, Anastasia Krivoruchko et al

FEMS Yeast Research. Vol. 15 (4)

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2015

Enabling Technologies to Advance Microbial Isoprenoid Production

Yun Chen, Yongjin Zhou, Verena Siewers et al

Advances in Biochemical Engineering/Biotechnology. Vol. 148, p. 143-160

Journal article

2014

Altered sterol composition renders yeast thermotolerant

Luis Caspeta-Guadarrama, Yun Chen, PAYAM GHIACI et al

Science. Vol. 346 (6205), p. 75-78

Journal article

2014

Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae

Yun Chen, Jichen Bao, Il-Kwon Kim et al

Metabolic Engineering. Vol. 22, p. 104-109

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2014

Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1

S. B. Shi, Yun Chen, Verena Siewers et al

mBio. Vol. 5 (3)

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2013

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks

Yun Chen, Jens B Nielsen

Current Opinion in Biotechnology. Vol. 24 (6), p. 956-972

Review article

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2013

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

Stefan Tippmann, Yun Chen, Verena Siewers et al

Biotechnology journal. Vol. 8 (12), p. 1435-1444

Review article

2013

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

Yun Chen, L. Daviet, M. Schalk et al

Metabolic Engineering. Vol. 15 (1), p. 48-54

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2013

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

Anastasia Krivoruchko, Cristina Serrano-Amatriain, Yun Chen et al

Journal of Industrial Microbiology and Biotechnology. Vol. 40 (9), p. 1051-1056

Journal article

2012

dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquiterpene alpha-santalene in a fed-batch mode

Gionata Scalcinati, Christoph Knuf, Siavash Partow et al

Metabolic Engineering. Vol. 14 (2), p. 91-103

Journal article

2012

Enhancing the copy number of episomal plasmids in Saccharomyces cerevisiae for improved protein production

Yun Chen, Siavash Partow, Gionata Scalcinati et al

FEMS Yeast Research. Vol. 12 (5), p. 598-607

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2012

Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae

Yun Chen, Verena Siewers, Jens B Nielsen

PLoS ONE. Vol. 7 (8), p. e42475-

Journal article

2012

Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae

Kanokarn Kocharin, Yun Chen, Verena Siewers et al

AMB Express. Vol. 2 (1)

Journal article

2011

Diversion of Flux toward Sesquiterpene Production in Saccharomyces cerevisiae by Fusion of Host and Heterologous Enzymes

L. Albertsen, Yun Chen, L. S. Bach et al

Applied and Environmental Microbiology. Vol. 77 (3), p. 1033-1040

Journal article

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Showing 10 research projects

2023–2026

Using metabolic modelling to identify new therapeutic targets for triple-negative breast cancer