Nathalie Scheers
Nathalie Scheers research focus is within the area of molecular nutrition. She and her team investigate intra/extracellular effects of absorbed nutrients e.g. metals, gluten, and the fish protein parvalbumin. This may involve the regulation of transport proteins and enzymes or stress responses that may lead to cancer, cell death, or oxidative damage. As research tools, they are using/developing single/co-culture human cell models and tissue cultures in addition to intervention studies in humans to translate in vitro results. Molecular aspects of iron nutrition relating to uptake routes and regulation. The intersection with zinc transport and the role in anemia of inflammation. Safe wheat for celiacs. We are developing a food additive with high affinity for the transglutaminase binding motive on gluten proteins, which is supposed to prevent gluten peptides to become immunogenic during the gastrointestinal passage. The fish protein beta-parvalbumin and its possible role in neurodegenerative disease. As an alternative reason other than fatty acids, to why eating fish is associated with less cognitive decline. We have a few pieces of the puzzle elucidated; Beta-parvalbumin is absorbed by humans and can be measured in blood and it interferes with amyloid formation of the ‘Parkinson protein’ alpha-synuclein in vitro. We are conducting a nested control study with focus on incident Alzheimer’s disease and the association with Beta-parvalbumin levels and fish intake. Air pollution particles from e.g. trains brakes, car- and truck tires, are deposited in the airways and pulmonary tissue. We are investigating how these particles and their metal cargo are affecting the epithelium, their absorption and the biological effect. Ph.D. student Jonna Hellsten (Ongoing): Tentative thesis title: Zinc and iron containing supplements in inflammatory intestinal disease: Mechanistic studies in cell and tissue cultures. (2024-) Ph.D. student Agata Tarczykowska. Thesis title: Exploring the effect of iron-ligand interactions on iron uptake pathways and inflammatory response in human cell lines (2020-2025) Ph.D. student Niklas Engström. Toward celiac-safe foods: Investigation of the interaction between transglutaminase 2 and gluten (2013-2018) Ph.D. student Cecilia Tullberg (2013-2018, co-supervisor) Ph.D. student Nikul Soni (2013- 2017, co-supervisor) Postdoc Darja Dobermann (2019-2020 Postdoc Niklas Engström (2018-2019) Postdoc Swarnim Gupta (2018-2019) Postdoc Shokoufeh Karimi (2018-2019) Post-doc Linnea Quirist (2017-2018, co-supervisor) Lisa Marie Witte (Cellular particle accumulation, 2023-24) Robin Rydbergh (Cellular particle accumulation, 2023-24) Leo Andrekson (Dietary determinants Alzheimer’s disease, Spring 2024) Linnea Svärd (Dietary determinants Alzheimer’s disease, Fall 2024) Nathalie Vahlund (Dietary determinants Alzheimer’s disease, Fall 2025)Research areas
Supervision postgraduate level
Supervision undergraduate amanuensis students
Master students
Showing 45 publications
ToF-SIMS analyses of brake wear particles in human epithelial Caco-2 cells
Current and Expected Trends for the Marine Chitin/Chitosan and Collagen Value Chains
Grains - a major source of sustainable protein for health
May Chelated Iron Be Pro-Inflammatory?
Potential Negative Effects of Whole grain Consumption
Brain foods - the role of diet in brain performance and health
Cytotoxic Effects of Digested Edible Insects on Intestinal Epithelia
The development of a novel ferric phytate compound for iron fortification of bouillons (part I)
Copper nanoparticles have negligible direct antibacterial impact
Abundant fish protein inhibits α-synuclein amyloid formation
Phytic acid - Properties, Uses and Determination
Increased Ferric Iron Species in Lactic Fermented Vegetables May Improve Iron Absorption
Vitamin B12 as a potential compliance marker for fish intake
Ascorbate-induced iron transport through ferroportin involves IRP2 and HIF2 alpha
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies
The iron transporter ferroportin is regulated by ascorbate
Usefulness of microbial phytase to improve zinc and iron bioavailability
Impaired uptake of beta-carotene by Caco-2 human intestinal cells in the presence of iron
Ascorbic acid uptake affects ferritin, Dcytb and Nramp2 expression in Caco-2 cells
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Showing 10 research projects
Pollution and subcellular effects – the connection to non-communicable diseases
Pollution and subcellular accumulation of metals – the connection to non-communicable diseases
Commercial exploitation of marine collagen and chitin from marine sources (BlueCC