Fredrik Westerlund
Fredrik Westerlunds forskargrupp studerar enstaka DNA-molekyler in nanokanaler med hjälp av fluorescensmikroskopi. Fokus ligger både på att utveckla nya metoder för att kartlägga DNA sekvenser så väl som att studera DNA-proteininteraktioner.
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Visar 187 publikationer
Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex
Fluorescence Microscopy of Nanochannel-Confined DNA
Nanofluidics for analysing DNA-protein interactions on the single DNA molecule level
Nanofluidics highlights importance of CtIP's tetrameric structure for DNA repair
Probing physical properties of single amyloid fibrils using nanofluidic channels
Plasmonic polymer nanoantenna arrays for electrically tunable and electrode-free metasurfaces
Single molecule experiments highlight the role of NBS1 and Xrs2 in DNA tethering by MRN and MRX
A Click Chemistry-Based Artificial Metallo-Nuclease
Strain-level bacterial typing directly from patient samples using optical DNA mapping
A single-molecule view on non-homologous end-joining in bacteria
Thermodynamics and kinetics of the B-S transition in base-modified DNA
Probing physical properties of single amyloid fibrils using nanofluidic channels
Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System
Nanofluidic Trapping of Faceted Colloidal Nanocrystals for Parallel Single-Particle Catalysis
Organic Anisotropic Excitonic Optical Nanoantennas
HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells
DNA in Nanochannels - Theory and Applications
Left versus right: Exploring the effects of chiral threading intercalators using optical tweezers
Nanofluidics for single DNA molecule analysis of DNA repair
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction
Combining dense and sparse labeling in optical DNA mapping
CRISPR/CAS9 BASED DNA-COMBING ASSAY FOR DETECTING ANTIMICROBIAL RESISTANCE GENES ON PLASMIDS
Mechanical characterization of base analogue modified nucleic acids by force spectroscopy
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin
Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents
A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids
Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion
Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein
A Nanofluidic Device for Multiplexed Analysis of Single Exosomes
Cultivation-Free Typing of Bacteria Using Optical DNA Mapping
Effect of Chirality on the Elastic Properties of the DNA-Threading Binuclear Ruthenium Complex
Studying the Intramolecular Forces of Base-Modified Nucleic Acids using Optical Tweezers
Phosphorylated CtIP bridges DNA to promote annealing of broken ends
Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples
Alpha-Synuclein Binds to DNA and Modulates its Physical Properties
Enzyme-free optical DNA mapping of the human genome using competitive binding
A nanofluidic device for parallel single nanoparticle catalysis in solution
Bacterial identification by optical mapping of genomic DNA in nanofluidic channels
Alpha-Synuclein Modulates the Physical Properties of DNA
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis
Hairpins in the conformations of a confined polymer
PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction
Interactions between DNA and HIV-1 Nucleocapsid Protein Studied using Nanofluidic Channels
Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids
Bacterial response to graphene oxide and reduced graphene oxide integrated in agar plates
Fluorescence microscopy of nanochannel-confined DNA
Stochastic unfolding of nanoconfined DNA: Experiments, model and Bayesian analysis
Identification and DNA annotation of a plasmid isolated from Chromobacterium violaceum
Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms
Optical DNA mapping in nanofluidic devices: principles and applications
Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms
Exploring DNA-protein interactions on the single DNA molecule level using nanofluidic tools
A nano flow cytometer for single lipid vesicle analysis
Vitamin C Pretreatment Enhances the Antibacterial Effect of Cold Atmospheric Plasma
Noise reduction in single time frame optical DNA maps
Applications of optical DNA mapping in microbiology
Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation
Significance of Steric Bulk in DNA Threading Intercalation Revelaed through Force-Dependent Kinetics
Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels
Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels
Rapid Tracing of Resistance Plasmids in a Nosocomial Outbreak Using Optical DNA Mapping
Super-Resolution Genome Mapping in Silicon Nanochannels
Detailed characterization of plasmids carrying resistance genes using optical DNA mapping
DNA intercalation optimized by two-step molecular lock mechanism
Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics
Extension of nanoconfined DNA: quantitative comparison between experiment and theory
Using nanofluidic channels to probe dynamics of RAD51-Filaments
Resolving the DNA Binding Mode of a Rotationally Flexible Binuclear Ruthenium Complex
The Role of the Threading Moiety in DNA Threading Intercalation by Ruthenium Dimer Complexes
Unfolding of nanoconfined circular DNA
Evidence for hydrophobic catalysis of DNA strand exchange
Bacteriophage strain typing by rapid single molecule analysis
Fast size-determination of intact bacterial plasmids using nanofluidic channels
Single-molecule electronics: from chemical design to functional devices
Probing Physical Properties of a DNA- Protein Complex Using Nanofluidic Channels
Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments
Quantifying the DNA Binding Kinetics of a Ruthenium Dimer Complex with a Flexible Linker
Kinetics of DNA Threading Intercalation by a Rigid Ruthenium Complex Dimer
Probing the Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels
Assessing How Cationic Intercalators Affect DNA using Nanofluidic Channels
Turn-On, Fluorescent Nuclear Stains with Live Cell Compatibility
Base Pair Sensitivity and Enhanced ON/OFF Ratios of DNA-Binding: Donor-Acceptor-Donor Fluorophores
What do photons do to fluorescently stained DNA in confinement?
Quantifying Force-Dependent Binding Kinetics of DNA-Ruthenium Complexes
Probing physical properties of DNA-protein complexes using nanofluidic channels
Monomer distributions and intrachain collisions of a polymer confined to a channel
Identifying bacteria using DNA binding maps
Assessing how cationic intercalators affect DNA using nanofluidic channels
A single-step competitive binding assay for mapping of single DNA molecules
Orientational correlations in confined DNA
Lipid-Based Passivation in Nanofluidics
A lipid-based passivation scheme for nanofluidics
Direct probing of ion pair formation using a symmetric triangulenium dye
Columnar Self-Assembly and Alignment of Planar Carbenium Ions in Langmuir-Blodgett Films
Local conformation of confined DNA studied using emission polarization anisotropy
Local conformation of confined DNA studied using emission polarization anisotropy
DNA strand exchange catalyzed by molecular crowding in PEG solutions
Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor
Fluorescence Enhancement of Single DNA Molecules Confined in Si/SiO2 Nanochannels
Fluorescence enhancement from single DNA molecules confined in SiO 2 nanochannels
Fluorescence Enhancement From Single DNA Molecules Confined In Si/SiO2 Nanochannels
Mechanism of DNA Strand Exchange at Liposome Surfaces Investigated Using Mismatched DNA
Complex DNA binding kinetics resolved-by combined circular dichroism and luminescence analysis
Enhanced DNA strand exchange on positively charged liposomes
DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate
Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.
Mechanically manipulating the DNA threading intercalation rate
Binding geometry and photophysical properties of DNA-threading binuclear ruthenium complexes
AT-dependent luminescence of DNA-threading ruthenium complexes
Kinetic characterization of an extremely slow DNA binding equilibrium
Kinetic recognition of AT-rich DNA by ruthenium complexes
On semirigid binuclear ruthenium complexes and DNA : binding modes and kinetics
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Visar 25 forskningsprojekt
Nanochannel Microscopy for Single Exosome Analysis
Enkelmolykylanalys av RNA-baserade terapier
Förbättrad diagnos för barn med leukemi genom moderna DNA-analys
Förbättrad kemoterapi för barn med cancer
Next generationdiagnostics of bacterial infections
Visualisering av DNA-Reparation - En Molekyl i Taget
Identifying molecular mechanisms causing sensitivity to chemotherapy
Next Generation Nanofluidic Devices for Single Molecule Analysis of DNA Repair Dynamics
Förbättrad cancerbehandling av barn känsliga för DNA-skador
Förbättrad diagnos av akut leukemi hos barn
Basal oxidative damage level assay (BODLA)
Individanpassning av cancerbehandling med cellgifter genom direkt mätning av DNA-skador
A novel ultrafast method for detecting multiresistant bacteria in intensive care units
Mätning av DNA-skador som ett sätt att individanpassa cancerbehandling med cellgifter
Bärbar diagnostik för sjukdom och antibiotikaresistans med fokus på malaria och bakterieinfektioner
Characterization of bacterial plasmids on a smartphone
Studier av DNA-reparation på enskilda DNA-molekyler
Genomic diagnostics beyond the sequence (BeyondSeq)
Odlingsfri identifiering av antibiotikaresistens
Nanofluidics for ultrafast diagnosis of bacterial infections (NanoDiaBac)
En nanofluidisk plattform för studier av biomolekyler på enkelmolekylnivå